SCHEMBL380137

SCHEMBL380137

CCn1cnc2c(=O)[nH]c(=O)[nH]c21

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNP P00491 2/20 0.50
ADORA2A P29274 3/20 0.40
PDE4A P27815 2/20 0.40
PDE4B Q07343 2/20 0.40
PDE4C Q08493 2/20 0.40
PDE4D Q08499 2/20 0.40
BRD4 O60885 4/20 0.38
BRD2 P25440 2/20 0.38
BRD3 Q15059 2/20 0.38
BRDT Q58F21 2/20 0.38
GDA Q9Y2T3 1/20 0.38
ADORA1 P30542 1/20 0.37
PI4KA P42356 1/20 0.37
PI4K2B Q8TCG2 1/20 0.37
PI4K2A Q9BTU6 1/20 0.37
PI4KB Q9UBF8 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
GAA P10253 1/20 0.36
CDK1 P06493 1/20 0.36
CCNB1 P14635 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7217325 0.98 PNP (0.49) PNPADORA2APDE4APDE4BPDE4C
SCHEMBL5054173 0.87 PNP (0.54) PNPADORA2APDE4APDE4BPDE4C
SCHEMBL6233163 0.84 PNP (0.58) PNPADORA2APDE4APDE4BPDE4C
SCHEMBL5428518 0.83 GAA (0.40) PNPADORA2APDE4APDE4BPDE4C
SCHEMBL27277482 0.83 ALDH1A1 (0.52) PNPADORA2APDE4APDE4BPDE4C
SCHEMBL24499702 0.83 PNP (0.48) PNPADORA2APDE4APDE4BPDE4C
SCHEMBL9885862 0.83 PNP (0.45) PNPSMN1; SMN2KMT2AALDH1A1
SCHEMBL27586845 0.83 PNP (0.53) PNPGDASMN1; SMN2KMT2AALDH1A1
SCHEMBL27573642 0.83 PNP (0.50) PNPGDASMN1; SMN2KMT2AALDH1A1
SCHEMBL9386892 0.82 PNP (0.47) PNPGDAPI4KAPI4K2BPI4K2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3946353-A1 COMPOUNDS FOR USE IN THE TREATMENT OF ADCY5-RELATED DYSKINESIA ASSISTANCE PUBLIQUE, HOPITAUX DE PARIS (FR) 2022-02-09 EP claimed
WO-2020193567-A1 COMPOUNDS FOR USE IN THE TREATMENT OF ADCY5-RELATED DYSKINESIA ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (FR) 2020-10-01 WO claimed
US-5700369-A Process for adsorboaggregational flotation of Carlin type natural gold ore dressing GUANGZHOU INSTITUTE OF GEOCHEMISTRY CHINESE ACADEMY OF SCIENCES (CN) 1997-12-23 US claimed
CN-122029936-A Light-emitting element, display device, and method for manufacturing light-emitting element 夏普显示科技株式会社 2026-05-12 CN disclosed
CN-115745998-B Method for synthesizing gouache mushroom and analogue thereof by photocatalysis 新乡学院 2024-10-22 CN disclosed
EP-3946353-A1 COMPOUNDS FOR USE IN THE TREATMENT OF ADCY5-RELATED DYSKINESIA ASSISTANCE PUBLIQUE, HOPITAUX DE PARIS (FR) 2022-02-09 EP disclosed
US-11149051-B2 Compositions and methods of modulating the immune response by activating alpha protein kinase 1 SHANGHAI YAO YUAN BIOTECHNOLOGY CO., LTD. (CN) 2021-10-19 US disclosed
EP-3765014-A1 METHODS AND COMPOSITIONS OF INHIBITING CSF1R FOR TREATING ALLERGIC INFLAMMATION THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2021-01-20 EP disclosed
US-20200113924-A1 CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT MERCK SHARP & DOHME CORP. (US) 2020-04-16 US disclosed
WO-2019204604-A1 METHODS AND COMPOSITIONS OF INHIBITING CSF1R FOR TREATING ALLERGIC INFLAMMATION THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2019-10-24 WO disclosed
US-20180179242-A1 CATALYSTS AND METHODS FOR POLYMER SYNTHESIS NOVOMER, INC. 2018-06-28 US disclosed
WO-1995007082-A1 A COMBINATION TABLET COMPRISING ACETYLSALICYLIC ACID AND A PROCESS FOR THE PREPARATION THEREOF EGIS Gyógyszergyár Rt. (HU) 1995-03-16 WO disclosed
EP-0528951-A4 HUMANIZED CDR-GRAFTED ANTI-ICAM-1 ANTIBODIES, METHODS OF PREPARATION AND USAGE THEREOF 1993-05-26 EP disclosed
EP-0528951-A1 HUMANIZED CDR-GRAFTED ANTI-ICAM-1 ANTIBODIES, METHODS OF PREPARATION AND USAGE THEREOF CELLTECH LIMITED (GB) 1993-03-03 EP disclosed
EP-0502043-A1 UTILIZATION OF XANTHINES, OPTIONALLY INCORPORATED IN LIPOSOMES IN ORDER TO HELP THE PIGMENTATION OF SKIN OR HAIR. LVMH RECH (FR) 1992-09-09 EP disclosed
WO-1992007566-A2 ANTIFUNGAL ACTIVITY OF AND PREVENTION OF DRUG INDUCED NEPHROTOXICITY BY METHYLXANTHINE ANALOGUES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1992-05-14 WO disclosed
EP-0480934-A1 A SLIMMING PHARMACEUTICAL COMPOSITION. DAK LAB AS (DK) 1992-04-22 EP disclosed
WO-1991016927-A1 HUMANIZED CDR-GRAFTED ANTI-ICAM-1 ANTIBODIES, METHODS OF PREPARATION AND USAGE THEREOF CELLTECH LIMITED (GB) 1991-11-14 WO disclosed
WO-1991007945-A1 UTILIZATION OF XANTHINES, OPTIONALLY INCORPORATED IN LIPOSOMES IN ORDER TO HELP THE PIGMENTATION OF SKIN OR HAIR LVMH RECHERCHE (FR) 1991-06-13 WO disclosed
WO-1991000730-A1 A SLIMMING PHARMACEUTICAL COMPOSITION DAK-LABORATORIET A/S (DK) 1991-01-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11149051-B2 Compositions and methods of modulating the immune response by activating alpha protein kinase 1 PHKA1, PHKA2, PRKCA PNP 1202/4885ADORA2A 368/4885PDE4A 574/4885
US-20180179242-A1 CATALYSTS AND METHODS FOR POLYMER SYNTHESIS PPOX, COASY, SOD1 PNP 950/4885ADORA2A 4627/4885PDE4A 4210/4885
US-20200113924-A1 CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT STING1, CGAS, MAVS PNP 348/4885ADORA2A 900/4885PDE4A 47/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.