Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | CCR4 | P51679 | 2/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13063827 | 0.90 | LMNA (0.39) | SRCWDR5CCR4MAP2K1BRD4 | |
| SCHEMBL13063540 | 0.89 | SRC (0.37) | SRCWDR5CCR4MAP2K1TP53 | |
| SCHEMBL3804823 | 0.88 | ADRA2A (0.36) | SRCWDR5CCR4MAP2K1ADRA2B | |
| SCHEMBL13063861 | 0.88 | MAP2K1 (0.48) | MAP2K1HSD17B10MAPTKMT2AKDM4E | |
| SCHEMBL13063568 | 0.87 | MAP2K1 (0.46) | MAP2K1 | |
| SCHEMBL3809160 | 0.86 | LRRK2 (0.35) | SRCWDR5CCR4MAP2K1HSD17B10 | |
| SCHEMBL3804582 | 0.86 | MAP2K1 (0.42) | MAP2K1TP53TSHRMAPTKMT2A | |
| SCHEMBL13063542 | 0.85 | SRC (0.36) | SRCWDR5CCR4MAP2K1BRD4 | |
| SCHEMBL13063539 | 0.85 | SRC (0.35) | SRCCCR4MAPTALDH1A1RAD52 | |
| SCHEMBL3801437 | 0.85 | ALDH1A1 (0.44) | TP53MAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |