Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
| ▸ | BRD1 | O95696 | 7/20 | 0.45 |
| ▸ | BRPF1 | P55201 | 7/20 | 0.45 |
| ▸ | BRPF3 | Q9ULD4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3804582 | 0.90 | MAP2K1 (0.42) | MAP2K1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL3804902 | 0.88 | MAP2K1 (0.62) | MAP2K1BRD1BRPF1BRPF3MEN1 | |
| SCHEMBL13063853 | 0.88 | SRC (0.38) | MAP2K1MEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL3803390 | 0.87 | MAP2K1 (0.35) | MAP2K1BRD1BRPF1BRPF3MEN1 | |
| SCHEMBL13063827 | 0.86 | LMNA (0.39) | MAP2K1BRPF1HSD17B10ALDH1A1HPGD | |
| SCHEMBL13063540 | 0.85 | SRC (0.37) | MAP2K1KMT2AHSD17B10MAPTHPGD | |
| SCHEMBL3801437 | 0.85 | ALDH1A1 (0.44) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL3804823 | 0.84 | ADRA2A (0.36) | MAP2K1BRPF1TRIM24 | |
| SCHEMBL3809160 | 0.83 | LRRK2 (0.35) | MAP2K1HSD17B10HPGD | |
| SCHEMBL13063539 | 0.82 | SRC (0.35) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |