Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 2/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13063827 | 0.93 | LMNA (0.39) | SRCWDR5CCR4MAP2K1CHEK1 | |
| SCHEMBL13063542 | 0.91 | SRC (0.36) | SRCWDR5CCR4MAP2K1CHEK1 | |
| SCHEMBL3809160 | 0.89 | LRRK2 (0.35) | SRCWDR5CCR4MAP2K1CHEK1 | |
| SCHEMBL13063589 | 0.89 | MAP2K1 (0.43) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL13063853 | 0.89 | SRC (0.38) | SRCWDR5CCR4MAP2K1LMNA | |
| SCHEMBL13063539 | 0.89 | SRC (0.35) | SRCCCR4MAPT | |
| SCHEMBL13063861 | 0.85 | MAP2K1 (0.48) | MAP2K1HPGDHSD17B10KMT2AMAPT | |
| SCHEMBL3804823 | 0.85 | ADRA2A (0.36) | SRCWDR5CCR4MAP2K1CHEK1 | |
| SCHEMBL3804582 | 0.83 | MAP2K1 (0.42) | MAP2K1LMNATSHRKMT2ATP53 | |
| SCHEMBL3801437 | 0.82 | ALDH1A1 (0.44) | LMNAKMT2ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |