Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | PRCP | P42785 | 8/20 | 0.38 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL381532 | 0.89 | PRCP (0.38) | HTR2AHTR2CPRCPGPR17CHRM2 | |
| Trifluoroacetic Acid SCHEMBL381380 | 0.83 | TP53 (0.39) | PRCPCHRM2CHRM1CHRM3SLC2A1 | |
| Trifluoroacetic Acid SCHEMBL381484 | 0.82 | P2RY14 (0.37) | CHRM2SLC2A1HSD11B1FPR2 | |
| SCHEMBL3564422 | 0.81 | HTR2A (0.43) | HTR2AHTR2CCHRM2CHRM1CHRM3 | |
| SCHEMBL3564428 | 0.81 | HTR2A (0.43) | HTR2AHTR2CCHRM2CHRM1CHRM3 | |
| Trifluoroacetic Acid SCHEMBL381517 | 0.81 | PAX8 (0.35) | CHRM2CHRM1CHRM3SLC2A1HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL381863 | 0.81 | AKR1C2 (0.41) | HTR2CCHRM2CHRM1CHRM3HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL381171 | 0.80 | P2RX7 (0.40) | HTR2AHTR2CCHRM2CHRM1CHRM3 | |
| Trifluoroacetic Acid SCHEMBL380699 | 0.79 | FFAR4 (0.35) | HTR2A | |
| Trifluoroacetic Acid SCHEMBL380865 | 0.78 | S1PR5 (0.38) | CHRM3HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049513-B1 | PIPERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-01-25 | — | — | EP | disclosed |