Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 11/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 2/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL712061 | 0.71 | SCN9A (0.56) | ALOX12PKMALDH1A1MEN1KMT2A | |
| SCHEMBL712133 | 0.71 | ALOX12 (0.63) | ALOX12PKMALDH1A1MEN1KMT2A | |
| SCHEMBL28338487 | 0.71 | SCN1A (0.57) | SCN9ASCN5ASCN1ASCN8A | |
| SCHEMBL28335404 | 0.69 | SCN1A (0.57) | SCN9ASCN5ASCN1ASCN8A | |
| SCHEMBL15211773 | 0.69 | PKM (0.65) | ALOX12PKMALDH1A1MEN1KMT2A | |
| SCHEMBL28762162 | 0.67 | CA2 (0.46) | ALDH1A1TP53 | |
| SCHEMBL322837 | 0.67 | GAA (0.60) | ALOX12ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL29835197 | 0.66 | SCN9A (0.46) | SCN9ASCN5ASCN1ASCN8A | |
| SCHEMBL9230514 | 0.65 | PKM (0.90) | ALOX12PKMALDH1A1MEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL3162475 | 0.64 | APLNR (0.50) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173743-A2 | SODIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009012242-A2 | SODIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 2009-01-22 | — | — | WO | disclosed |