Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9722931 | 0.80 | CES2 (0.44) | HTTCES2CES1IKBKBCLCN2 | |
| SCHEMBL3810854 | 0.80 | CLCN2 (0.52) | KMT2ACES2CES1IKBKBALDH1A1 | |
| SCHEMBL3811178 | 0.79 | ALDH1A1 (0.51) | KMT2AHTTNPC1ALDH1A1KDM4E | |
| SCHEMBL642910 | 0.78 | CES2 (0.61) | KMT2AHTTNPC1ATMCES2 | |
| SCHEMBL9744146 | 0.77 | KDM4E (0.58) | NPC1ATMALDH1A1KDM4EMAPT | |
| SCHEMBL27731731 | 0.76 | HSP90AB1 (0.43) | KMT2AHTTCES2CES1IKBKB | |
| SCHEMBL9722911 | 0.76 | IKBKB (0.38) | KMT2AHTTCES2CES1IKBKB | |
| SCHEMBL30612342 | 0.75 | ALDH1A1 (0.46) | KMT2AHTTNPC1ATMCES2 | |
| SCHEMBL3811988 | 0.75 | KEAP1 (0.47) | KMT2AHTTNPC1ATMCES2 | |
| SCHEMBL30032063 | 0.75 | NPC1 (0.61) | KMT2AHTTNPC1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524855-B2 | Selected benzofuran derivatives | ARPIDA AG (CH) | 2009-04-28 | — | — | US | disclosed |
| US-20080108610-A1 | Selected Benzofuran Derivatives | ARPIDA AG (CH) | 2008-05-08 | — | — | US | disclosed |
| EP-1838704-A1 | SELECTED BENZOFURAN DERIVATIVES | Arpida AG (CH) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006072370-A1 | SELECTED BENZOFURAN DERIVATIVES | ARPIDA AG (CH) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108610-A1 | Selected Benzofuran Derivatives | ABCG2, BPTF, SBDS | KMT2A 3464/4885HTT 2085/4885NPC1 1404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.