Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 18/20 | 0.77 |
| ▸ | PPARA | Q07869 | 10/20 | 0.77 |
| ▸ | PPARG | P37231 | 5/20 | 0.77 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5512756 | 0.92 | PPARD (0.65) | PPARDPPARAPPARGFFAR1FFAR2 | |
| SCHEMBL6493346 | 0.88 | PPARD (0.60) | PPARDPPARAPPARGPTPN1FFAR1 | |
| SCHEMBL1602178 | 0.87 | PPARD (1.00) | PPARDPPARAPPARG | |
| SCHEMBL4110321 | 0.85 | PPARD (0.82) | PPARDPPARAPPARG | |
| SCHEMBL5728665 | 0.85 | PPARD (0.55) | PPARDPPARAPPARGPTPN1FFAR1 | |
| SCHEMBL5728669 | 0.85 | PPARD (0.55) | PPARDPPARAPPARGPTPN1FFAR1 | |
| SCHEMBL4111994 | 0.82 | PPARD (0.67) | PPARDPPARAPPARG | |
| SCHEMBL3819076 | 0.81 | PPARD (0.70) | PPARDPPARAPPARG | |
| SCHEMBL1548952 | 0.80 | PPARD (0.71) | PPARDPPARAPPARG | |
| SCHEMBL5511665 | 0.79 | PPARD (0.68) | PPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6875780-B2 | Compounds that modulate PPAR activity and methods for their preparation | WARNER-LAMBERT COMPANY (US) | 2005-04-05 | — | — | US | claimed |
| EP-1819681-B1 | 7-(2H-PYRAZOL-3-YL)-3,5-DIHYDROXY-HEPTANOIC ACID DERIVATIVES AS HMG CO-A REDUCTASE INHIBITORS FOR THE TREATMENT OF LIPIDEMIA | WARNER LAMBERT CO (US) | 2009-08-12 | — | — | EP | disclosed |
| US-20090170852-A1 | NOVEL PYRAZOLE-BASED HMG CoA REDUCTASE INHIBITORS | PFIZER INC. | 2009-07-02 | — | — | US | disclosed |
| US-7446121-B2 | Pyrazole-based HMG CoA reductase inhibitors | PFIZER INC. (US) | 2008-11-04 | — | — | US | disclosed |
| US-20080227974-A1 | Novel Substituted Azetidinones | PFIZER INC. | 2008-09-18 | — | — | US | disclosed |
| EP-1912937-A1 | NOVEL SUBSTITUTED AZETIDINONES | Warner-Lambert Company LLC (US) | 2008-04-23 | — | — | EP | disclosed |
| US-RE39916-E1 | Compounds that modulate PPAR activity and methods for their preparation | WARNER LAMBERT COMPANY (US) | 2007-11-06 | — | — | US | disclosed |
| US-RE39916-E1 | Compounds that modulate PPAR activity and methods for their preparation | WARNER LAMBERT COMPANY (US) | 2007-11-06 | — | — | US | disclosed |
| US-RE39916-E1 | Compounds that modulate PPAR activity and methods for their preparation | WARNER LAMBERT COMPANY (US) | 2007-11-06 | — | — | US | disclosed |
| EP-1819681-A1 | 7-(2H-PYRAZOL-3-YL)-3,5-DIHYDROXY-HEPTANOIC ACID DERIVATIVES AS HMG CO-A REDUCTASE INHIBITORS FOR THE TREATMENT OF LIPIDEMIA | Warner-Lambert Company LLC (US) | 2007-08-22 | — | — | EP | disclosed |
| US-6964983-B2 | Compounds that modulate PPAR activity and methods for their preparation | WARNER-LAMBERT COMPANY, LLC (US) | 2005-11-15 | — | — | US | disclosed |
| WO-2005105079-A2 | NOVEL IMIDAZOLES | WARNER-LAMBERT COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |
| US-20050239857-A1 | Novel imidazoles | BOLTON GARY L | 2005-10-27 | — | — | US | disclosed |
| US-6939875-B2 | Carbocyclic oxy sulfides such as [4-(Biphenyl-4-ylmethylsulfanyl)-5-methoxy-2-methyl-phenoxy]-acetic acid, used to control peroxisome proliferator activated receptors (PPAR), for prophylaxis of metabolic disorders | WARNER-LAMBERT COMPANY (US) | 2005-09-06 | — | — | US | disclosed |
| US-20050153996-A1 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS FOR THEIR PREPARATION | AUERBACH BRUCE J (US) | 2005-07-14 | — | — | US | disclosed |
| US-20050154042-A1 | N-alkyl pyrroles as HMG-CoA reductase inhibitors | WARNER-LAMBERT COMPANY | 2005-07-14 | — | — | US | disclosed |
| US-20050113440-A1 | Compounds that modulate PPAR activity and methods for their preparation | AUERBACH BRUCE J (US) | 2005-05-26 | — | — | US | disclosed |
| EP-1494989-A2 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS FOR THEIR PREPARATION | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-12 | — | — | EP | disclosed |
| US-20030225158-A1 | Compounds that modulate PPAR activity and methods for their preparation | WARNER-LAMBERT COMPANY | 2003-12-04 | — | — | US | disclosed |
| WO-2003084916-A2 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS FOR THEIR PREPARATION | WARNER-LAMBERT COMPANY LLC (US) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170852-A1 | NOVEL PYRAZOLE-BASED HMG CoA REDUCTASE INHIBITORS | HMGCR, BPHL, CYP46A1 | PPARD 182/4885PPARA 123/4885PPARG 141/4885 |
| US-20030225158-A1 | Compounds that modulate PPAR activity and methods for their preparation | GPR119, PPARA, PPARG | PPARD 4/4885PPARA 2/4885PPARG 3/4885 |
| US-20050113440-A1 | Compounds that modulate PPAR activity and methods for their preparation | GPR119, PPARA, PPARG | PPARD 4/4885PPARA 2/4885PPARG 3/4885 |
| US-20080227974-A1 | Novel Substituted Azetidinones | APOB, PCSK9, CYP46A1 | PPARD 278/4885PPARA 695/4885PPARG 662/4885 |
| US-20050239857-A1 | Novel imidazoles | HMGCR, HMGB2, HMGB3 | PPARD 1124/4885PPARA 967/4885PPARG 739/4885 |
| US-20050153996-A1 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS FOR THEIR PREPARATION | GPR119, PPARA, PPARG | PPARD 4/4885PPARA 2/4885PPARG 3/4885 |
| US-20050154042-A1 | N-alkyl pyrroles as HMG-CoA reductase inhibitors | HMGCR, DHCR7, CYP11A1 | PPARD 765/4885PPARA 306/4885PPARG 540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.