Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.36 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.36 |
| ▸ | RPA1 | P27694 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.34 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3814191 | 0.86 | HSD11B1 (0.35) | HSD11B1HSD11B2P2RX7CNR1CNR2 | |
| SCHEMBL3815221 | 0.82 | NR1H4 (0.36) | NR1H4HSD11B1RPA1P2RX7CNR1 | |
| SCHEMBL3813756 | 0.81 | RPA1 (0.45) | RPA1SMN1; SMN2L3MBTL1PPP1CA | |
| SCHEMBL3816741 | 0.78 | SRD5A2 (0.36) | NR1H4HSD11B1HSD11B2P2RX7CNR2 | |
| SCHEMBL3820671 | 0.77 | ALDH1A1 (0.34) | NR1H4SMN1; SMN2P2RX7L3MBTL1ALDH1A1 | |
| SCHEMBL3813472 | 0.73 | TSHR (0.33) | HSD11B1CNR2CA12CA2CA9 | |
| SCHEMBL3815943 | 0.69 | CNR2 (0.37) | HSD11B1HSD11B2P2RX7CNR2L3MBTL1 | |
| SCHEMBL3815358 | 0.68 | LMNA (0.34) | SMN1; SMN2CNR2ALDH1A1NPSR1 | |
| SCHEMBL30971768 | 0.66 | TP53 (0.45) | SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL13720006 | 0.65 | CNR2 (0.39) | SMN1; SMN2CNR1CNR2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |