Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | HNF4A | P41235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2572169 | 0.85 | AKR1C1 (0.42) | MAPTMEN1KMT2A | |
| SCHEMBL11289324 | 0.78 | AKR1C1 (0.48) | MEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL26135641 | 0.78 | AKR1C1 (0.44) | MEN1KMT2A | |
| SCHEMBL11275197 | 0.77 | AKR1C1 (0.47) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11736962 | 0.76 | NPC1 (0.45) | FFAR1NPC1RAB9AGRM5MAPT | |
| SCHEMBL4849593 | 0.75 | PARP15 (0.41) | NPC1RAB9ALMNACA1CA2 | |
| SCHEMBL2720401 | 0.75 | CA1 (0.37) | RAB9AMEN1KMT2ASMN1; SMN2CA12 | |
| SCHEMBL28108261 | 0.75 | CA1 (0.36) | LMNACA1CA2 | |
| SCHEMBL28755810 | 0.75 | HDAC4 (0.41) | — | |
| SCHEMBL23647372 | 0.74 | OPRM1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391623-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010088177-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-08-05 | — | — | WO | disclosed |