SCHEMBL381791

SCHEMBL381791

Clc1ccccc1-c1nc(-c2ccccc2)[nH]c1-c1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAPK13 O15264 11/20 0.67
MAPK12 P53778 11/20 0.67
MAPK11 Q15759 11/20 0.67
MAPK14 Q16539 11/20 0.67
RAF1 P04049 8/20 0.67
MAPK9 P45984 1/20 0.57
GCGR P47871 3/20 0.55
MGAM O43451 1/20 0.54
BRAF P15056 2/20 0.53
NOX1 Q9Y5S8 1/20 0.51
KDM4E B2RXH2 1/20 0.50
POLB P06746 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30514842 1.00 MAPK13 (0.67) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL8114499 0.93 MAPK13 (0.76) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL15401233 0.88 MAPK14 (0.68) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL10078946 0.87 MAPK13 (0.86) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL1040038 0.87 MAPK13 (0.67) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL306063 0.87 MAPK13 (0.67) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL29360656 0.87 MAPK13 (0.67) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL14124514 0.86 MAPK13 (0.64) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL14060614 0.86 MAPK13 (0.55) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL31305575 0.86 MAPK13 (0.55) MAPK13MAPK12MAPK11MAPK14RAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6551710-B1 Primer composition comprises dithiol or polythiol compound and allyl or vinyl monomer; coating composition can further comprise photochromic dyes and additional polymerizable monomers; coatings for lenses SOLA INTERNATIONAL HOLDINGS, LTD. (AU) 2003-04-22 US claimed
WO-1999038924-A1 COATING COMPOSITION SOLA INTERNATIONAL HOLDINGS LTD. (AU) 1999-08-05 WO claimed
EP-0842236-A4 PHOTOCHROMIC POLYMER SOLA INT HOLDINGS (AU) 1998-10-21 EP claimed
EP-0842236-A1 PHOTOCHROMIC POLYMER SOLA INTERNATIONAL HOLDINGS, LTD. (AU) 1998-05-20 EP claimed
WO-1997027223-A1 PROCESS FOR PREPARING OPTICAL ARTICLES SOLA INTERNATIONAL HOLDINGS LTD. (AU) 1997-07-31 WO claimed
WO-1997005213-A1 PHOTOCHROMIC POLYMER SOLA INTERNATIONAL HOLDINGS LTD. (AU) 1997-02-13 WO claimed
US-12600879-B2 Coated lens and method for manufacturing the same CARL ZEISS VISION INTERNATIONAL GMBH (DE) 2026-04-14 US disclosed
EP-4493966-A2 COATED LENS AND METHOD FOR MANUFACTURING THE SAME Carl Zeiss Vision International GmbH (DE) 2025-01-22 EP disclosed
US-20240417588-A1 COATED LENS AND METHOD FOR MANUFACTURING THE SAME CARL ZEISS VISION INTERNATIONAL GMBH (DE) 2024-12-19 US disclosed
WO-2023175193-A2 COATED LENS AND METHOD FOR MANUFACTURING THE SAME CARL ZEISS VISION INTERNATIONAL GMBH (DE) 2023-09-21 WO disclosed
US-11754860-B2 Photochromic lens with laminated film, method for producing a photochromic lens, and a spectacle frame CARL ZEISS VISION INTERNATIONAL GMBH (DE) 2023-09-12 US disclosed
CN-116157741-A Transfer film, method for producing laminate, and method for producing circuit wiring 富士胶片株式会社 2023-05-23 CN disclosed
US-20210156739-A1 Wearable UV Exposure Sensor BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT 2021-05-27 US disclosed
EP-0797786-A4 INCORPORATING PHOTOCHROMIC MOLECULES IN LIGHT TRANSMISSIBLE ARTICLES SOLA INT HOLDINGS (AU) 1998-12-09 EP disclosed
EP-0797786-A1 INCORPORATING PHOTOCHROMIC MOLECULES IN LIGHT TRANSMISSIBLE ARTICLES SOLA INTERNATIONAL HOLDINGS, LTD. (AU) 1997-10-01 EP disclosed
WO-1997027223-A1 PROCESS FOR PREPARING OPTICAL ARTICLES SOLA INTERNATIONAL HOLDINGS LTD. (AU) 1997-07-31 WO disclosed
WO-1996018928-A1 INCORPORATING PHOTOCHROMIC MOLECULES IN LIGHT TRANSMISSIBLE ARTICLES SOLA INTERNATIONAL HOLDINGS LTD. (AU) 1996-06-20 WO disclosed
WO-1996018927-A1 A PHOTOCHROMIC LIGHT-TRANSMISSIBLE ARTICLE SOLA INTERNATIONAL HOLDINGS LTD. (AU) 1996-06-20 WO disclosed
EP-0320900-B1 PROCESS FOR PREPARING NEGATIVE IMAGES ON A POSITIVE-TYPE TONABLE PHOTOSENSITIVE ELEMENT E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-08-04 EP disclosed
EP-0320900-A2 Process for preparing negative images on a positive-type tonable photosensitive element E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-06-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12600879-B2 Coated lens and method for manufacturing the same GMFG, AQP4, METTL14 MAPK13 3090/4885MAPK12 3727/4885MAPK11 3629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.