Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PAM | P19021 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28092757 | 0.81 | LMNA (0.53) | LMNAPAMALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL7715841 | 0.74 | CES1 (0.43) | PAMALDH1A1MAPK1L3MBTL1CES2 | |
| SCHEMBL3480743 | 0.74 | CES1 (0.48) | LMNAPAMALDH1A1MAPK1L3MBTL1 | |
| Benzyl Carbamate SCHEMBL11791684 | 0.73 | AKR1B1 (0.63) | LMNAPAMALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL7715836 | 0.73 | CES1 (0.42) | LMNAPAMALDH1A1MAPK1L3MBTL1 | |
| Benzyl Carbamate SCHEMBL30227887 | 0.72 | ALDH1A1 (0.63) | LMNAALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| Benzyl Carbamate SCHEMBL10700633 | 0.72 | ALDH1A1 (0.63) | LMNAALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| Benzyl Carbamate SCHEMBL30227819 | 0.72 | ALDH1A1 (0.63) | LMNAALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| Benzyl Carbamate SCHEMBL1697 | 0.72 | ALDH1A1 (0.63) | LMNAALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| Phenylacetic Acid SCHEMBL27915710 | 0.71 | AKR1B1 (0.61) | LMNAPAMALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2096111-A1 | PYRAZOLES AND USE THEREOF AS DRUGS | Japan Tobacco Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| US-20090036450-A1 | PYRAZOLE COMPOUNDS AND USE THEREOF | JAPAN TOBACCO, INC. (JP) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036450-A1 | PYRAZOLE COMPOUNDS AND USE THEREOF | PYGL, GYS2, G6PC1 | LMNA 2209/4885PAM 1981/4885ALDH1A1 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.