Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ME2 | P23368 | 1/20 | 0.41 |
| ▸ | ME1 | P48163 | 1/20 | 0.41 |
| ▸ | ME3 | Q16798 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3827281 | 0.99 | AGER (0.54) | AGERRAB9AHTR2ASLC6A9SLC6A5 | |
| SCHEMBL8179598 | 0.90 | HTR2A (0.57) | AGERRAB9AHTR2ASLC6A9SLC6A5 | |
| SCHEMBL3823818 | 0.89 | AGER (0.48) | AGERHTR2ASLC6A9SLC6A5KMT2A | |
| SCHEMBL4737202 | 0.83 | SLC6A9 (0.43) | AGERHTR2ASLC6A9SLC6A5KMT2A | |
| SCHEMBL4739773 | 0.83 | SLC6A9 (0.45) | AGERHTR2ASLC6A9SLC6A5KMT2A | |
| SCHEMBL3826982 | 0.82 | RAB9A (0.54) | RAB9AHTR2AKMT2AME2ME1 | |
| SCHEMBL3066199 | 0.82 | DRD2 (0.43) | RAB9ASLC6A9SLC6A5SMN1; SMN2L3MBTL1 | |
| SCHEMBL3828512 | 0.81 | GAA (0.49) | HTR2ASLC6A9SLC6A5L3MBTL1 | |
| SCHEMBL3822555 | 0.80 | RAB9A (0.52) | RAB9AKMT2AME2ME1ME3 | |
| SCHEMBL3822411 | 0.79 | RAB9A (0.51) | RAB9AHTR2AKMT2AME2ME1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |