Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3823818 | 0.84 | AGER (0.48) | HTR2AALDH1A1SLC6A9SLC6A5 | |
| SCHEMBL8179598 | 0.83 | HTR2A (0.57) | HTR2AALDH1A1L3MBTL1SLC6A9SLC6A5 | |
| SCHEMBL3827281 | 0.82 | AGER (0.54) | HTR2AL3MBTL1SLC6A9SLC6A5 | |
| SCHEMBL3827832 | 0.81 | AGER (0.53) | HTR2AL3MBTL1SLC6A9SLC6A5 | |
| SCHEMBL4737202 | 0.81 | SLC6A9 (0.43) | HSD17B10HTR2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL4739773 | 0.80 | SLC6A9 (0.45) | HSD17B10HTR2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL3066199 | 0.80 | DRD2 (0.43) | L3MBTL1SLC6A9SLC6A5 | |
| SCHEMBL3860666 | 0.76 | RORC (0.45) | HSD17B10HTR2AALDH1A1L3MBTL1 | |
| SCHEMBL3824036 | 0.75 | L3MBTL1 (0.55) | ALDH1A1L3MBTL1MAPT | |
| SCHEMBL4735222 | 0.73 | SMO (0.40) | HSD17B10HTR2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |