Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1367799 | 0.88 | MAPT (0.51) | MAPTL3MBTL1TDP1POLBKMT2A | |
| SCHEMBL31098212 | 0.82 | CES1 (0.45) | MAPTALDH1A1LMNATP53ABL1 | |
| SCHEMBL380110 | 0.81 | ALOX5 (0.61) | MAPTL3MBTL1TDP1POLBKMT2A | |
| SCHEMBL3409888 | 0.81 | AHR (0.49) | MAPTL3MBTL1TDP1POLBKMT2A | |
| SCHEMBL13929961 | 0.81 | MAPT (0.48) | MAPTL3MBTL1TDP1POLBKMT2A | |
| SCHEMBL172370 | 0.81 | LMNA (0.58) | MAPTL3MBTL1TDP1POLBKMT2A | |
| SCHEMBL9270079 | 0.81 | CSNK1G1 (0.56) | MAPTL3MBTL1TDP1POLBKMT2A | |
| SCHEMBL1368116 | 0.81 | ACE2 (0.64) | MAPTL3MBTL1TDP1POLBKMT2A | |
| SCHEMBL766354 | 0.80 | ALOX5 (0.65) | MAPTL3MBTL1TDP1POLBKMT2A | |
| SCHEMBL31098238 | 0.80 | ACE2 (0.59) | ABL1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1593676-B1 | 8-Chloro-11-(4-(2'-hydroxyethyl)piperazin-1-yl)-dibenzo[b,f][1,4]oxazepine of atypical anti-psychotic activity and having a low affinity for the dopamine D2 receptor | CAMH (CA) | 2009-10-07 | — | — | EP | disclosed |
| US-20090149442-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2009-06-11 | — | — | US | disclosed |
| EP-1406881-B8 | 11-PIPERAZINYLDIBENZO(B,F)(1,4)OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | CAMH (CA) | 2006-10-25 | — | — | EP | disclosed |
| EP-1406881-B1 | 11-PIPERAZINYLDIBENZO(B,F)(1,4)OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | NEUROMOLECULAR INC (CA) | 2006-09-13 | — | — | EP | disclosed |
| US-20060166965-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2006-07-27 | — | — | US | disclosed |
| EP-1593676-A1 | 8-Chloro-11-(4-(2'-hydroxyethyl)piperazin-1-yl)-dibenzo[b,f][1,4]oxazepine of atypical anti-psychotic activity and having a low affinity for the dopamine D2 receptor | Neuromolecular, Inc. (CA) | 2005-11-09 | — | — | EP | disclosed |
| US-20050222121-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2005-10-06 | — | — | US | disclosed |
| US-6890919-B2 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ (CA) | 2005-05-10 | — | — | US | disclosed |
| EP-1406881-A1 | 11-PIPERAZINYLDIBENZO(B,F)(1,4)OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | Neuromolecular, Inc. (CA) | 2004-04-14 | — | — | EP | disclosed |
| US-20030135042-A1 | Atypical antipsychotic agents having low affinity for the D2 Receptor | NEUROMOLECULAR, INC. (CA) | 2003-07-17 | — | — | US | disclosed |
| WO-2003000670-A1 | A11-PIPERAZINYLDIBENZO (B, F) (1, 4) OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | NEUROMOLECULAR, INC. (CA) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149442-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | DRD2, OPRD1, GRIN2A | MAPT 1444/4885L3MBTL1 4796/4885TDP1 4461/4885 |
| US-20050222121-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | DRD2, OPRD1, GRIN2A | MAPT 1444/4885L3MBTL1 4796/4885TDP1 4461/4885 |
| US-20060166965-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | DRD2, OPRD1, GRIN2A | MAPT 1444/4885L3MBTL1 4796/4885TDP1 4461/4885 |
| US-20030135042-A1 | Atypical antipsychotic agents having low affinity for the D2 Receptor | OPRD1, HTR1A, DRD2 | MAPT 1543/4885L3MBTL1 4729/4885TDP1 4180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.