Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.30 |
| ▸ | CDC25B | P30305 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL385932 | 0.98 | LMNA (0.59) | LMNABLMPTPN1MEN1CYP3A4 | |
| SCHEMBL386505 | 0.80 | — | — | |
| SCHEMBL2120409 | 0.78 | OPRM1 (0.42) | LMNA | |
| SCHEMBL383797 | 0.78 | LMNA (0.31) | LMNA | |
| SCHEMBL383875 | 0.78 | LMNA (0.31) | LMNA | |
| SCHEMBL386591 | 0.78 | LMNA (0.31) | LMNA | |
| SCHEMBL11517915 | 0.76 | ACE2 (0.44) | LMNA | |
| SCHEMBL386581 | 0.76 | LMNA (0.34) | LMNA | |
| SCHEMBL387540 | 0.76 | LMNA (0.34) | LMNA | |
| SCHEMBL386571 | 0.76 | LMNA (0.34) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150141502-A1 | INHIBITION OF LEUKEMIC STEM CELLS BY PP2A ACTIVATING AGENTS | Ohio State Innvation Foundation (US) | 2015-05-21 | — | — | US | claimed |
| EP-2418948-B1 | ANTIADHESION AGENTS | UNIV OHIO STATE RES FOUND (US) | 2013-09-04 | — | — | EP | claimed |
| US-8461362-B2 | Protein phosphatase 2A-activating agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-06-11 | — | — | US | claimed |
| US-8362071-B2 | Antiadhesion agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-01-29 | — | — | US | claimed |
| EP-2419414-A1 | PROTEIN PHOSPHATASE 2A-ACTIVATING AGENTS | The Ohio State University Research Foundation (US) | 2012-02-22 | — | — | EP | claimed |
| EP-2418948-A1 | ANTIADHESION AGENTS | The Ohio State University Research Foundation (US) | 2012-02-22 | — | — | EP | claimed |
| WO-2010121111-A9 | ANTIADHESION AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-12-22 | — | — | WO | claimed |
| US-20100267820-A1 | ANTIADHESION AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-10-21 | — | — | US | claimed |
| US-20100267673-A1 | PROTEIN PHOSPHATASE 2A-ACTIVATING AGENTS | THE OHIO SATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-10-21 | — | — | US | claimed |
| WO-2010121111-A1 | ANTIADHESION AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120711-A1 | PROTEIN PHOSPHATASE 2A-ACTIVATING AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-10-21 | — | — | WO | claimed |
| US-4125735-A | Synthesis of esters of acetylenic alcohols | SCM CORPORATION (US) | 1978-11-14 | — | — | US | claimed |
| US-4115466-A | ACETYLENIC HYDROCARBONS FROM ACETYLENIC CARBINOLS, ISOMERIZATION | SCM CORPORATION (US) | 1978-09-19 | — | — | US | claimed |
| US-9220706-B2 | Inhibition of leukemic stem cells by PP2A activating agents | NATIONAL INSTITUTES OF HEALTH (NIH) (US) | 2015-12-29 | — | — | US | disclosed |
| US-9220706-B2 | Inhibition of leukemic stem cells by PP2A activating agents | NATIONAL INSTITUTES OF HEALTH (NIH) (US) | 2015-12-29 | — | — | US | disclosed |
| US-20150141502-A1 | INHIBITION OF LEUKEMIC STEM CELLS BY PP2A ACTIVATING AGENTS | Ohio State Innvation Foundation (US) | 2015-05-21 | — | — | US | disclosed |
| US-20030236297-A1 | Amino alcohol derivatives | SANKYO COMPANY, LIMITED (JP) | 2003-12-25 | — | — | US | disclosed |
| EP-1300405-A1 | AMINO ALCOHOL DERIVATIVES | Sankyo Company, Limited (JP) | 2003-04-09 | — | — | EP | disclosed |
| US-4125735-A | Synthesis of esters of acetylenic alcohols | SCM CORPORATION (US) | 1978-11-14 | — | — | US | disclosed |
| US-4039591-A | 1-ACETOXY-4-CHLORO-3-METHYLBUT-2-ENE | SCM CORPORATION (US) | 1977-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236297-A1 | Amino alcohol derivatives | CD4, ADH1C, ADH1A | LMNA 3703/4885BLM 4551/4885PTPN1 2617/4885 |
| US-20100267673-A1 | PROTEIN PHOSPHATASE 2A-ACTIVATING AGENTS | PPP2CA, PPP2R2A, PPP2R1A | LMNA 3602/4885BLM 4530/4885PTPN1 386/4885 |
| US-20150141502-A1 | INHIBITION OF LEUKEMIC STEM CELLS BY PP2A ACTIVATING AGENTS | PPM1A, PPM1G, PPM1F | LMNA 3971/4885BLM 4068/4885PTPN1 38/4885 |
| US-20100267820-A1 | ANTIADHESION AGENTS | SELE, EPCAM, SELP | LMNA 2725/4885BLM 3727/4885PTPN1 4843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.