Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.37 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL383745 | 1.00 | CA2 (0.39) | CA2CA4ALDH1A1HDAC3HDAC4 | |
| Cinnamic Acid SCHEMBL30442198 | 0.86 | MAPT (0.53) | ALDH1A1HDAC3HDAC4HDAC1HDAC2 | |
| Acrylic Acid SCHEMBL4444810 | 0.84 | AKT1 (0.45) | CA2CA4ALDH1A1LMNAMAPT | |
| Acetic Acid SCHEMBL1140944 | 0.81 | CA2 (0.42) | CA2CA4ALDH1A1MAPTSMN1; SMN2 | |
| Fumaric Acid SCHEMBL105911 | 0.77 | CA2 (0.39) | CA2CA4ALDH1A1HDAC3HDAC4 | |
| Fumaric Acid SCHEMBL105908 | 0.77 | CA2 (0.39) | CA2CA4ALDH1A1HDAC3HDAC4 | |
| Fumaric Acid SCHEMBL105267 | 0.77 | CA2 (0.39) | CA2CA4ALDH1A1HDAC3HDAC4 | |
| Fumaric Acid SCHEMBL11588378 | 0.76 | CA2 (0.42) | CA2CA4ALDH1A1HDAC3HDAC4 | |
| SCHEMBL384455 | 0.76 | CA2 (0.38) | CA2CA4ALDH1A1LMNAMAPT | |
| SCHEMBL384453 | 0.76 | CA2 (0.38) | CA2CA4ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3456746-B1 | TERMINAL-MODIFIED CONJUGATED DIENE-BASED POLYMER, RUBBER COMPOSITION, AND RUBBER ARTICLE | BRIDGESTONE CORP (JP) | 2023-04-19 | — | — | EP | disclosed |
| CN-109891375-B | Touch panel and method for manufacturing touch panel | 东丽株式会社 | 2022-04-12 | — | — | CN | disclosed |
| EP-3851489-A1 | MODIFIED MULTI-COMPONENT COPOLYMER, RUBBER COMPOSITION, RESIN COMPOSITION, TIRE AND RESIN PRODUCT | BRIDGESTONE CORPORATION (JP) | 2021-07-21 | — | — | EP | disclosed |
| US-10875937-B2 | Terminal-modified conjugated diene polymer, rubber composition and rubber article | BRIDGESTONE CORPORATION (JP) | 2020-12-29 | — | — | US | disclosed |
| CN-109071685-B | Terminal-modified conjugated diene polymer, rubber composition, and rubber article | 株式会社普利司通 | 2020-12-01 | — | — | CN | disclosed |
| WO-2020054484-A1 | MODIFIED MULTI-COMPONENT COPOLYMER, RUBBER COMPOSITION, RESIN COMPOSITION, TIRE AND RESIN PRODUCT | 株式会社ブリヂストン | 2020-03-19 | — | — | WO | disclosed |
| US-20190161571-A1 | TERMINAL-MODIFIED CONJUGATED DIENE POLYMER, RUBBER COMPOSITION, RUBBER PRODUCT AND METHOD FOR MANUFACTURING TERMINAL-MODIFIED CONJUGATED DIENE POLYMER | BRIDGESTONE CORPORATION (JP) | 2019-05-30 | — | — | US | disclosed |
| US-20190153123-A1 | TERMINAL-MODIFIED CONJUGATED DIENE POLYMER, RUBBER COMPOSITION AND RUBBER ARTICLE | BRIDGESTONE CORPORATION (JP) | 2019-05-23 | — | — | US | disclosed |
| EP-3466985-A1 | TERMINALLY MODIFIED CONJUGATED DIENE POLYMER, RUBBER COMPOSITION, RUBBER PRODUCT, AND METHOD FOR PRODUCING TERMINALLY MODIFIED CONJUGATED DIENE POLYMER | Bridgestone Corporation (JP) | 2019-04-10 | — | — | EP | disclosed |
| EP-3456746-A1 | TERMINAL-MODIFIED CONJUGATED DIENE-BASED POLYMER, RUBBER COMPOSITION, AND RUBBER ARTICLE | Bridgestone Corporation (JP) | 2019-03-20 | — | — | EP | disclosed |
| EP-1026181-B1 | Method of producing conjugated diene polymer | JSR CORP (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-20040147694-A1 | Method of producing conjugated diene polymers with narrow molecular weight distribution and polymer produced | JSR CORPORATION | 2004-07-29 | — | — | US | disclosed |
| EP-0957115-B1 | Method for producing conjugated diene polymers | JSR CORP (JP) | 2003-12-03 | — | — | EP | disclosed |
| EP-0863165-B1 | Method of producing conjugated diene polymers | JSR CORP (JP) | 2003-06-04 | — | — | EP | disclosed |
| US-6391990-B1 | Method of producing conjugated diene polymer | JSR CORPORATION (JP) | 2002-05-21 | — | — | US | disclosed |
| US-6255416-B1 | POLYMERIZING CONJUGATED DIENE COMPOUND WITH CATALYST CONSISTING ESSENTIALLY OF COMPOUND CONTAINING RARE EARTH ELEMENT, ALUMOXANE, ORGANOALUMINUM COMPOUND, REACTION PRODUCT OF METAL HALIDE AND LEWIS BASE | JSR CORPORATION (JP) | 2001-07-03 | — | — | US | disclosed |
| EP-1026181-A1 | Method of producing conjugated diene polymer | JSR Corporation (JP) | 2000-08-09 | — | — | EP | disclosed |
| EP-0957115-A1 | Method for producing conjugated diene polymers | JSR Corporation (JP) | 1999-11-17 | — | — | EP | disclosed |
| EP-0863165-A1 | Method of producing conjugated diene polymers | JSR Corporation (JP) | 1998-09-09 | — | — | EP | disclosed |
| US-4281076-A | CURING AT LOW TEMPERATURE, COMPRISING A DIBASIC ACID, A BLOCKED ISOCYANATE AND A TIN COMPOUND | KANSAI PAINT COMPANY, LIMITED (JP) | 1981-07-28 | — | — | US | disclosed |