Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.53 |
| ▸ | BCL2 | P10415 | 1/20 | 0.53 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.53 |
| ▸ | BAD | Q92934 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446595 | 0.96 | MCL1 (0.54) | MCL1BCL2BCL2L1BADTSHR | |
| SCHEMBL11416328 | 0.90 | MCL1 (0.52) | MCL1BCL2BCL2L1BADTSHR | |
| SCHEMBL4672754 | 0.86 | MCL1 (0.65) | MCL1BCL2BCL2L1BADTSHR | |
| SCHEMBL5273001 | 0.84 | CAPN1 (0.56) | MCL1BCL2BCL2L1BADTSHR | |
| SCHEMBL18227970 | 0.81 | KDM4E (0.47) | — | |
| SCHEMBL19861154 | 0.81 | MAPT (0.54) | MCL1BCL2BCL2L1BADTSHR | |
| Acetic Acid SCHEMBL27918017 | 0.81 | KDM4E (0.51) | TSHRMAPK1MEN1KMT2A | |
| SCHEMBL1860716 | 0.81 | MAOB (0.43) | — | |
| SCHEMBL1864115 | 0.80 | ALDH1A1 (0.60) | TSHRMAPK1MEN1KMT2A | |
| SCHEMBL17997088 | 0.80 | MAPT (0.52) | MCL1BCL2BCL2L1BADTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382224-B2 | 7-acyloxychromen-4-one derivatives and the use thereof as self-tanning substances | MERCK PATENT GMBH (DE) | 2016-07-05 | — | — | US | disclosed |
| US-9044409-B2 | Use of chromen-4-one derivatives | MERCK PATENT GMBH (DE) | 2015-06-02 | — | — | US | disclosed |
| US-20130287716-A1 | 7-ACYLOXYCHROMEN-4-ONE DERIVATIVES AND THE USE THEREOF AS SELF-TANNING SUBSTANCES | MERCK PATENT GMBH (DE) | 2013-10-31 | — | — | US | disclosed |
| US-20090220438-A1 | CHROMEN-4-ONE DERIVATIVES AS SELF-TANNING SUBSTANCE | MERCK PATENT GMBH (DE) | 2009-09-03 | — | — | US | disclosed |
| US-20090209637-A1 | USE OF CHROMEN-4-ONE DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 2009-08-20 | — | — | US | disclosed |
| EP-2056782-A1 | USE OF CHROMEN-4-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008025368-A1 | USE OF CHROMEN-4-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-03-06 | — | — | WO | disclosed |
| US-20080027133-A1 | USE OF CHROMEN-4-ONE DERIVATIVES | CAROLA CHRISTOPHE | 2008-01-31 | — | — | US | disclosed |
| US-20070191305-A1 | Chromone complexes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2007-08-16 | — | — | US | disclosed |
| CN-1938289-A | Chromone complexes | MERCK PATENT GMBH (DE) | 2007-03-28 | — | — | CN | disclosed |
| US-20060292093-A1 | Chromen-4-one derivatives | MERCK PATENT GMBH (DE) | 2006-12-28 | — | — | US | disclosed |
| CN-1835940-A | Chromen-4-one derivatives | MERCK PATENT GMBH (DE) | 2006-09-20 | — | — | CN | disclosed |
| US-20050043398-A1 | Use of chromen-4-one derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209637-A1 | USE OF CHROMEN-4-ONE DERIVATIVES | CBR1, CYP46A1, CCR8 | MCL1 3888/4885BCL2 2410/4885BCL2L1 2400/4885 |
| US-20130287716-A1 | 7-ACYLOXYCHROMEN-4-ONE DERIVATIVES AND THE USE THEREOF AS SELF-TANNING SUBSTANCES | TYR, CYP7B1, CYP46A1 | MCL1 4881/4885BCL2 4868/4885BCL2L1 4870/4885 |
| US-20070191305-A1 | Chromone complexes | SCO2, CDYL, CYCS | MCL1 1180/4885BCL2 2743/4885BCL2L1 3266/4885 |
| US-20090220438-A1 | CHROMEN-4-ONE DERIVATIVES AS SELF-TANNING SUBSTANCE | C9, CYP8B1, TYR | MCL1 3692/4885BCL2 3562/4885BCL2L1 3483/4885 |
| US-20080027133-A1 | USE OF CHROMEN-4-ONE DERIVATIVES | CYP8B1, CYP7B1, CYP2R1 | MCL1 2361/4885BCL2 1531/4885BCL2L1 1284/4885 |
| US-20050043398-A1 | Use of chromen-4-one derivatives | CYP8B1, CYP7B1, CYP2R1 | MCL1 2321/4885BCL2 1542/4885BCL2L1 1281/4885 |
| US-20060292093-A1 | Chromen-4-one derivatives | TYR, XPA, CYP19A1 | MCL1 3811/4885BCL2 3729/4885BCL2L1 3768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.