Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 6/20 | 0.47 |
| ▸ | CHKA | P35790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6358947 | 0.90 | DAO (0.51) | DAONPC1POLBRAB9AALDH1A1 | |
| SCHEMBL20593165 | 0.86 | CYP1A2 (0.55) | DAONPC1POLBRAB9AALDH1A1 | |
| SCHEMBL1721002 | 0.85 | NPC1 (0.57) | DAONPC1POLBRAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL27757950 | 0.84 | CYP1A2 (0.53) | DAONPC1POLBRAB9AALDH1A1 | |
| Bromide SCHEMBL27470539 | 0.84 | CYP1A2 (0.53) | DAONPC1POLBRAB9AALDH1A1 | |
| SCHEMBL25354572 | 0.82 | DAO (0.57) | DAONPC1POLBRAB9AALDH1A1 | |
| SCHEMBL5528688 | 0.82 | ALDH1A1 (0.55) | DAONPC1POLBRAB9AALDH1A1 | |
| SCHEMBL2597877 | 0.82 | ALDH1A1 (0.59) | DAONPC1POLBRAB9AALDH1A1 | |
| SCHEMBL5546704 | 0.82 | DAO (0.54) | DAONPC1POLBRAB9AALDH1A1 | |
| SCHEMBL30173448 | 0.82 | DAO (0.57) | DAONPC1POLBRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3325497-B1 | QUINSTATIN COMPOUNDS | UNIV ARIZONA STATE (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3325497-B1 | QUINSTATIN COMPOUNDS | UNIV ARIZONA STATE (US) | 2020-09-02 | — | — | EP | disclosed |
| US-10435435-B2 | Quinstatin compounds | THE ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2019-10-08 | — | — | US | disclosed |
| US-20180371012-A1 | QUINSTATIN COMPOUNDS | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2018-12-27 | — | — | US | disclosed |
| EP-3325497-A1 | QUINSTATIN COMPOUNDS | Pettit, George, Robert (US) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017019489-A1 | QUINSTATIN COMPOUNDS | PETTIT GEORGE ROBERT (US) | 2017-02-02 | — | — | WO | disclosed |
| WO-2017019489-A1 | QUINSTATIN COMPOUNDS | PETTIT GEORGE ROBERT (US) | 2017-02-02 | — | — | WO | disclosed |
| US-8314087-B2 | Nitrogen-containing heterocyclyl ketones and methods of use | AMGEN INC. (US) | 2012-11-20 | — | — | US | disclosed |
| EP-2114898-A2 | NITROGEN-CONTAINING HETEROCYCLYL KETONES AND THEIR USE AS C-MET INHIBITORS | Amgen Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| US-20080280917-A1 | Nitrogen-Containing heterocyclyl ketones and methods of use | AMGEN INC. (US) | 2008-11-13 | — | — | US | disclosed |
| WO-2008103277-A2 | NITROGEN-CONTAINING HETEROCYCLYL KETONES AND THEIR USE AS C-MET INHIBITORS | AMGEN INC. (US) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280917-A1 | Nitrogen-Containing heterocyclyl ketones and methods of use | HGF, HGFAC, MET | DAO 1343/4885NPC1 312/4885POLB 1502/4885 |
| US-10435435-B2 | Quinstatin compounds | QTRT1, COQ8A, QPCT | DAO 1977/4885NPC1 1585/4885POLB 940/4885 |
| US-20180371012-A1 | QUINSTATIN COMPOUNDS | QTRT1, COQ8A, QPCT | DAO 1977/4885NPC1 1585/4885POLB 940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.