Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | EYA2 | O00167 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27905518 | 0.80 | KDM4E (0.33) | TDP1EYA2APPACEKDM4E | |
| Bromoacetic Acid SCHEMBL1064789 | 0.79 | TSHR (0.48) | LMNATSHRCA1CA12CA9 | |
| Succinic Acid SCHEMBL28916613 | 0.76 | LMNA (0.45) | PMP22KDM4ELMNATSHRCA1 | |
| Succinic Acid SCHEMBL722926 | 0.76 | LMNA (0.45) | PMP22KDM4ELMNATSHRCA1 | |
| Bicarbonate SCHEMBL14917 | 0.75 | CA1 (0.38) | KDM4ELMNATSHRCA1CA2 | |
| Bicarbonate SCHEMBL6150295 | 0.75 | CA1 (0.38) | KDM4ELMNATSHRCA1CA2 | |
| Edetic Acid SCHEMBL8607480 | 0.75 | TDP1 (1.00) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL15136 | 0.75 | TDP1 (1.00) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL8624198 | 0.75 | TDP1 (1.00) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL16714076 | 0.75 | TDP1 (1.00) | TDP1EYA2APPACEBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846019-B2 | Use of protoberberines as an active substance regulating the pilosebaceous unit | SEDERMA (FR) | 2014-09-30 | — | — | US | disclosed |
| US-20090269395-A1 | USE OF PROTOBERBERINES AS AN ACTIVE SUBSTANCE REGULATING THE PILOSEBACEOUS UNIT | SEDERMA (FR) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090269395-A1 | USE OF PROTOBERBERINES AS AN ACTIVE SUBSTANCE REGULATING THE PILOSEBACEOUS UNIT | BROX, CUTA, SHH | TDP1 4382/4885EYA2 1940/4885APP 1090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.