SCHEMBL384668

SCHEMBL384668

COC(=O)c1cc(COS(C)(=O)=O)nn1-c1ncccc1Cl

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC16A3 O15427 5/20 0.39
SLC16A1 P53985 4/20 0.39
ALDH1A1 P00352 1/20 0.35
CYP1A2 P05177 1/20 0.35
POLB P06746 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
KMT2A Q03164 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
MALT1 Q9UDY8 5/20 0.35
KDM4E B2RXH2 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
RBP4 P02753 1/20 0.35
DHODH Q02127 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25008752 0.88 SLC16A3 (0.41) SLC16A3SLC16A1ALDH1A1CYP1A2POLB
SCHEMBL341122 0.87 ALDH1A1 (0.37) SLC16A3SLC16A1ALDH1A1CYP1A2POLB
SCHEMBL340847 0.85 MALT1 (0.38) SLC16A3SLC16A1ALDH1A1CYP1A2POLB
SCHEMBL421559 0.85 MALT1 (0.38) SLC16A3SLC16A1ALDH1A1CYP1A2POLB
SCHEMBL2623669 0.85 MALT1 (0.39) SLC16A3SLC16A1ALDH1A1CYP1A2POLB
SCHEMBL30206595 0.85 MALT1 (0.38) SLC16A3SLC16A1ALDH1A1CYP1A2POLB
SCHEMBL4191327 0.84 SLC16A3 (0.39) SLC16A3SLC16A1MALT1RBP4DHODH
SCHEMBL341689 0.84 DHODH (0.38) SLC16A3SLC16A1ALDH1A1CYP1A2POLB
SCHEMBL16014672 0.84 MALT1 (0.37) SLC16A3SLC16A1ALDH1A1CYP1A2POLB
SCHEMBL28802119 0.83 ALDH1A1 (0.38) SLC16A3SLC16A1ALDH1A1CYP1A2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8222435-B2 Dioxolane and dioxane derivatives and a process for their preparation BAYER CROPSCIENCE AG (DE) 2012-07-17 US claimed
WO-2020016841-A1 A NOVEL PROCESS FOR THE PREPARATION OF ANTHRANILIC DIAMIDES PI INDUSTRIES LTD. (IN) 2020-01-23 WO disclosed
US-8946236-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2015-02-03 US disclosed
US-20130324560-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AG (DE) 2013-12-05 US disclosed
US-8586753-B2 Process for the preparation of 1-alkyl and 1-aryl-5-pyrazolecarboxylic acid derivatives BAYER CROPSCIENCE AG (DE) 2013-11-19 US disclosed
US-8586753-B2 Process for the preparation of 1-alkyl and 1-aryl-5-pyrazolecarboxylic acid derivatives BAYER CROPSCIENCE AG (DE) 2013-11-19 US disclosed
EP-2513063-B1 Method for manufacturing 1-alkyl-/1-aryl-5-pyrazolcarbonic acid derivatives BAYER CROPSCIENCE AG (DE) 2013-11-06 EP disclosed
EP-2513063-B1 Method for manufacturing 1-alkyl-/1-aryl-5-pyrazolcarbonic acid derivatives BAYER CROPSCIENCE AG (DE) 2013-11-06 EP disclosed
EP-2513082-B1 New dioxalane and dioxane derivatives and method for producing same BAYER CROPSCIENCE AG (DE) 2013-10-02 EP disclosed
US-8536092-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2013-09-17 US disclosed
US-20120094830-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AG (DE) 2012-04-19 US disclosed
US-8101550-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2012-01-24 US disclosed
US-20110152532-A1 Process For The Preparation Of 1-Alkyl And 1-Aryl-5-pyrazolecarboxylic Acid Derivatives BAYER CROPSCIENCE AG (DE) 2011-06-23 US disclosed
US-20110152532-A1 Process For The Preparation Of 1-Alkyl And 1-Aryl-5-pyrazolecarboxylic Acid Derivatives BAYER CROPSCIENCE AG (DE) 2011-06-23 US disclosed
US-20110152532-A1 Process For The Preparation Of 1-Alkyl And 1-Aryl-5-pyrazolecarboxylic Acid Derivatives BAYER CROPSCIENCE AG (DE) 2011-06-23 US disclosed
WO-2011073101-A1 METHOD FOR PRODUCING 1-ALKYL-/1-ARYL-5-PYRAZOLE-CARBOXYLIC ACID DERIVATIVES BAYER CROPSCIENCE AG (DE) 2011-06-23 WO disclosed
WO-2011073101-A1 METHOD FOR PRODUCING 1-ALKYL-/1-ARYL-5-PYRAZOLE-CARBOXYLIC ACID DERIVATIVES BAYER CROPSCIENCE AG (DE) 2011-06-23 WO disclosed
WO-2011073100-A1 NOVEL DIOXOLANE AND DIOXANE DERIVATIVES, AND A METHOD FOR THE PRODUCTION THEREOF BAYER CROPSCIENCE AG (DE) 2011-06-23 WO disclosed
US-20110152531-A1 Novel Dioxolane And Dioxane Derivatives And A Process For Their Preparation BAYER CROPSCIENCE AG (DE) 2011-06-23 US disclosed
US-20100029478-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-02-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152532-A1 Process For The Preparation Of 1-Alkyl And 1-Aryl-5-pyrazolecarboxylic Acid Derivatives AADAC, CYP4X1, CYP4Z1 SLC16A3 4612/4885SLC16A1 4345/4885ALDH1A1 317/4885
US-20100029478-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR SLC16A3 4072/4885SLC16A1 4076/4885ALDH1A1 2028/4885
US-20110152531-A1 Novel Dioxolane And Dioxane Derivatives And A Process For Their Preparation ACOX1, CYP4X1, ANTXR2 SLC16A3 4667/4885SLC16A1 4578/4885ALDH1A1 401/4885
US-20120094830-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR SLC16A3 4072/4885SLC16A1 4076/4885ALDH1A1 2028/4885
US-20130324560-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR SLC16A3 4072/4885SLC16A1 4076/4885ALDH1A1 2028/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.