Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 2/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FER | P16591 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8980802 | 0.79 | CHEK1 (0.44) | MAOBPTPRCSTK10SLKUSP2 | |
| SCHEMBL9110123 | 0.78 | MAOA (0.57) | CES1MAOBMAOAPDGFRAFER | |
| SCHEMBL4180952 | 0.78 | CES1 (0.50) | CES1MAOBMAOAPTPRCSTK10 | |
| SCHEMBL11202707 | 0.78 | PDE3B (0.51) | CES1MAOBMAOAALDH1A1PDGFRA | |
| Hydrochloric Acid SCHEMBL11214501 | 0.76 | PDE3B (0.50) | CES1MAOBMAOAALDH1A1PDGFRA | |
| SCHEMBL27554975 | 0.73 | PTPRC (0.54) | MAOBMAOAPTPRCALDH1A1TMIGD3 | |
| SCHEMBL8980813 | 0.71 | MEN1 (0.46) | MAOBPTPRCUSP2ALDH1A1TMIGD3 | |
| SCHEMBL14811237 | 0.71 | ALDH1A1 (0.50) | CES1MAOBMAOAALDH1A1LRRK2 | |
| SCHEMBL14812709 | 0.69 | MAOA (0.53) | CES1MAOBMAOAALDH1A1PDGFRA | |
| SCHEMBL26259994 | 0.67 | CYP2A6 (0.52) | MAOBPTPRCPDGFRACDK8TMIGD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140378451-A1 | Cannabinoid-2-Receptor Agonists | ISIS INNOVATION LIMITED (GB) | 2014-12-25 | — | — | US | disclosed |
| US-20140378451-A1 | Cannabinoid-2-Receptor Agonists | ISIS INNOVATION LIMITED (GB) | 2014-12-25 | — | — | US | disclosed |
| EP-2032135-A2 | METHOD OF MODULATING NEURITE OUTGROWTH BY THE USE OF A GALANIN-3 RECEPTOR ANTAGONIST | Helicon Therapeutics, Inc. (US) | 2009-03-11 | — | — | EP | disclosed |
| EP-1957067-A1 | INDOLONE COMPOUNDS USEFUL TO TREAT COGNITIVE IMPAIRMENT | Helicon Therapeutics, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2008002946-A2 | METHOD OF MODULATING NEURITE OUTGROWTH BY THE USE OF A GALANIN-3 RECEPTOR ANTAGONIST | HELICON THERAPEUTICS, INC. (US) | 2008-01-03 | — | — | WO | disclosed |
| WO-2007070362-A1 | INDOLONE COMPOUNDS USEFUL TO TREAT COGNITIVE IMPAIRMENT | HELICON THERAPEUTICS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378451-A1 | Cannabinoid-2-Receptor Agonists | CNR2, CNR1, GPR18 | CES1 1021/4885MAOB 2247/4885MAOA 2195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.