Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 9/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1950924 | 0.77 | PKM (0.39) | STK17BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3513089 | 0.69 | MAOA (0.41) | STK17BMEN1KMT2AMCL1RECQL | |
| SCHEMBL8466712 | 0.68 | PKM (0.52) | STK17BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL290477 | 0.66 | PKM (0.54) | STK17BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29707476 | 0.66 | PKM (0.54) | STK17BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL705239 | 0.63 | ACHE (0.39) | STK17BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5798008 | 0.63 | MIF (0.47) | ALDH1A1TYRMAOBMIFMAOA | |
| SCHEMBL2793464 | 0.60 | MAPK1 (0.48) | STK17BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3261837 | 0.59 | STK17B (0.50) | STK17BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8780706 | 0.59 | PKM (0.39) | STK17BHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2011489-A2 | Method to inhibit ischemia and reperfusion injury | Gottlieb, Roberta (US) | 2009-01-07 | — | — | EP | disclosed |
| EP-1523310-A2 | METHOD TO INHIBIT ISCHEMIA AND REPERFUSION INJURY | The Scripps Research Institute (US) | 2005-04-20 | — | — | EP | disclosed |
| WO-2004004702-A2 | METHOD TO INHIBIT ISCHEMIA AND REPERFUSION INJURY | THE SCRIPPS RESEARCH INSTITUTE (US) | 2004-01-15 | — | — | WO | disclosed |