SCHEMBL705239

SCHEMBL705239

COC1=CCC(=C2C(=O)Oc3ccccc3C2=O)C=C1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.39
STK17B O94768 5/20 0.36
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36
MIF P14174 2/20 0.34
PKM P14618 1/20 0.34
TSHR P16473 1/20 0.34
ALDH1A1 P00352 7/20 0.34
MAPT P10636 5/20 0.34
RAB9A P51151 3/20 0.34
NPSR1 Q6W5P4 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8780706 0.76 PKM (0.39) ACHESTK17BHDAC3HDAC4HDAC1
SCHEMBL29707476 0.67 PKM (0.54) ACHESTK17BHDAC3HDAC4HDAC1
SCHEMBL290477 0.67 PKM (0.54) ACHESTK17BHDAC3HDAC4HDAC1
SCHEMBL3513089 0.66 MAOA (0.41) STK17BMIFMAPTRAB9ANPC1
SCHEMBL8466712 0.65 PKM (0.52) ACHESTK17BHDAC3HDAC4HDAC1
SCHEMBL7172140 0.64 CYP19A1 (0.36) ACHESTK17BHDAC3HDAC4HDAC1
SCHEMBL7649436 0.63 ALOX15 (0.50) STK17BHDAC3HDAC4HDAC1HDAC7
SCHEMBL7649433 0.63 ALOX15 (0.50) STK17BHDAC3HDAC4HDAC1HDAC7
SCHEMBL31023502 0.63 ALOX15 (0.50) STK17BHDAC3HDAC4HDAC1HDAC7
SCHEMBL3848115 0.63 STK17B (0.38) ACHESTK17BHDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8124390-B2 Aromatic prenyltransferases, nucleic acids encoding same and uses therefor THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2012-02-28 US disclosed
US-20100285502-A1 NOVEL AROMATIC PRENYLTRANSFERASES, NUCLEIC ACIDS ENCODING SAME AND USES THEREFOR THE SALK INSTITUTE FOR BIOLOGICAL STUDIES TOUDAI TLO, LTD. 2010-11-11 US disclosed
US-7544498-B2 Aromatic prenyltransferases, nucleic acids encoding same and uses therefor THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2009-06-09 US disclosed
US-20080274478-A1 NOVEL AROMATIC PRENYLTRANSFERASES, NUCLEIC ACIDS ENCODING SAME AND USES THEREFOR THE SALK INSTITUTE FOR BIOLOGICAL STUDIES TOUDAI TOL, LTD. 2008-11-06 US disclosed
US-7361483-B2 Aromatic prenyltransferases, nucleic acids encoding same and uses therefor THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2008-04-22 US disclosed
US-20060183211-A1 Novel aromatic prenyltransferases, nucleic acids encoding same and uses therefor THE SALK INSTITUTE FOR BIOLOGICAL STUDIES TOUDAI TLO, LTD. 2006-08-17 US disclosed
WO-2006081537-A2 NOVEL AROMATIC PRENYLTRANSFERASES, NUCLEIC ACIDS ENCODING SAME AND USES THEREFOR THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2006-08-03 WO disclosed