Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464511 | 0.88 | MAPT (0.44) | MAPTCYP2C9CYP2C19KDM4EALDH1A1 | |
| SCHEMBL4470605 | 0.86 | NPC1 (0.40) | MAPTCYP2C9CYP2C19KDM4EALDH1A1 | |
| SCHEMBL4469804 | 0.85 | HTT (0.46) | MAPTCYP2C9CYP2C19KDM4EKMT2A | |
| SCHEMBL3850936 | 0.84 | GPR35 (0.43) | MAPTCYP2C9CYP2C19KDM4EALDH1A1 | |
| SCHEMBL4462942 | 0.83 | FADS1 (0.49) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3848659 | 0.81 | MEN1 (0.52) | MAPTKDM4EALDH1A1KMT2ANPSR1 | |
| SCHEMBL4459109 | 0.81 | RAF1 (0.41) | MAPTCYP2C9CYP2C19KDM4EALDH1A1 | |
| SCHEMBL27901583 | 0.80 | RXFP1 (0.55) | — | |
| SCHEMBL3855951 | 0.80 | NPSR1 (0.48) | MAPTCYP2C9CYP2C19ALDH1A1KMT2A | |
| SCHEMBL2299039 | 0.80 | RAF1 (0.54) | MAPTCYP2C9CYP2C19KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |