Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505636 | 0.89 | GPR119 (0.56) | MAPTDRD2DRD3HTR1AHTR2A | |
| SCHEMBL4509537 | 0.88 | ALDH1A1 (0.53) | MAPTDRD2DRD3HTR1AHTR2A | |
| SCHEMBL3844622 | 0.87 | DRD2 (0.49) | DRD2DRD3HTR2AHTR7 | |
| SCHEMBL27752805 | 0.85 | MAPT (0.44) | MAPTDRD2DRD3HTR1AHTR2A | |
| SCHEMBL6011450 | 0.85 | ALDH1A1 (0.56) | MAPTALDH1A1TSHRLMNAMAPK1 | |
| SCHEMBL3843639 | 0.83 | SMN1; SMN2 (0.48) | MAPTDRD2DRD3ALDH1A1TSHR | |
| SCHEMBL3845966 | 0.82 | DRD2 (0.46) | DRD2DRD3HTR7 | |
| SCHEMBL3845963 | 0.82 | DRD4 (0.51) | MAPTDRD2DRD3HTR7 | |
| SCHEMBL6420684 | 0.81 | ALOX5 (0.52) | MAPTDRD2ALDH1A1TSHRLMNA | |
| SCHEMBL3849039 | 0.78 | DRD2 (0.49) | DRD2DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038268-A2 | CARBONYLATED (AZA)CYCLOHEXANES AS DOPAMINE D3 RECEPTOR LIGANDS | BIOPROJET (FR) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007148208-A2 | CARBONYLATED (AZA) CYCLOHEXANES AS DOPAMINE D3 RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-27 | — | — | WO | disclosed |