SCHEMBL385176

SCHEMBL385176

NC(Cc1ccc(O)cc1[N+](=O)[O-])C(=O)O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIA2 P42262 2/20 0.51
KDM4E B2RXH2 2/20 0.50
ALDH1A1 P00352 2/20 0.50
LMNA P02545 2/20 0.50
CYP3A4 P08684 2/20 0.50
MAPT P10636 2/20 0.50
ALOX15 P16050 2/20 0.50
NFKB1 P19838 2/20 0.50
BLM P54132 2/20 0.50
PMP22 Q01453 2/20 0.50
KMT2A Q03164 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
HSD17B10 Q99714 2/20 0.50
HTR1A P08908 1/20 0.50
ADORA3 P0DMS8 1/20 0.50
TSHR P16473 1/20 0.50
HTR2A P28223 1/20 0.50
HTR2C P28335 1/20 0.50
SLC6A4 P31645 1/20 0.50
HTR7 P34969 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL385177 1.00 GRIA2 (0.51) GRIA2KDM4EALDH1A1LMNACYP3A4
SCHEMBL1817775 0.85 CYP1A2 (0.61) GRIA2ALDH1A1TSHRPTPRAHPGD
SCHEMBL1817774 0.85 CYP1A2 (0.61) GRIA2ALDH1A1TSHRPTPRAHPGD
SCHEMBL30959758 0.85 CYP1A2 (0.61) GRIA2ALDH1A1TSHRPTPRAHPGD
SCHEMBL2127356 0.84 GRIA2 (0.50) GRIA2KDM4EALDH1A1LMNACYP3A4
SCHEMBL17002633 0.84 GRIA2 (0.50) GRIA2KDM4EALDH1A1LMNACYP3A4
SCHEMBL652018 0.84 GRIA2 (0.56) GRIA2ALDH1A1CYP3A4ALOX15KMT2A
SCHEMBL11266099 0.83 ALOX15 (0.44) ALOX15HSD17B10L3MBTL1CYP1A2
SCHEMBL29054253 0.82 GRIA2 (0.44) GRIA2KDM4EALDH1A1LMNACYP3A4
SCHEMBL29054255 0.82 GRIA2 (0.44) GRIA2KDM4EALDH1A1LMNACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110922469-B Method for inhibiting human calcitonin aggregation 华中科技大学 2021-04-20 CN claimed
CN-110922469-A Method for inhibiting human calcitonin aggregation 华中科技大学 2020-03-27 CN claimed
EP-1991572-A2 PEPTIDES THAT BLOCK THE BINDING OF IGG TO FCRN SYNTONIX PHARMACEUTICALS, INC. (US) 2008-11-19 EP claimed
US-20070254831-A1 PEPTIDES THAT BLOCK THE BINDING OF IgG to FcRn BIOGEN HEMOPHILIA INC. 2007-11-01 US claimed
WO-2007098420-A2 PEPTIDES THAT BLOCK THE BINDING OF IGG TO FCRN SYNTONIX PHARMACEUTICALS, INC. (US) 2007-08-30 WO claimed
EP-4651906-A1 ANTI-CD70 ANTIBODY-DRUG CONJUGATES Ambrx, Inc. (US) 2025-11-26 EP disclosed
EP-4598586-A1 DRUG LINKERS AND ANTIBODY CONJUGATES THEREOF Ambrx, Inc. (US) 2025-08-13 EP disclosed
EP-3541829-B1 SUBSTANCES FOR TARGETING VARIOUS SELECTED ORGANS OR TISSUES ACADEMISCH ZIEKENHUIS LEIDEN (NL) 2025-07-16 EP disclosed
WO-2025041055-A1 ANTI-PSMA ADC CONJUGATE COMPOSITIONS AND METHODS OF USE THEREOF AMBRX, INC. (US) 2025-02-27 WO disclosed
WO-2024155627-A1 ANTI-CD70 ANTIBODY-DRUG CONJUGATES AMBRX, INC. (US) 2024-07-25 WO disclosed
WO-2024077277-A1 DRUG LINKERS AND ANTIBODY CONJUGATES THEREOF AMBRX, INC. (US) 2024-04-11 WO disclosed
US-11459358-B2 Substances for targeting various selected organs or tissues ACADEMISCH ZIEKENHUIS LEIDEN (NL) 2022-10-04 US disclosed
US-20080234183-A1 Cell Penetrating Peptides CEPEP II AB (SE) 2008-09-25 US disclosed
US-20070254831-A1 PEPTIDES THAT BLOCK THE BINDING OF IgG to FcRn BIOGEN HEMOPHILIA INC. 2007-11-01 US disclosed
WO-2007098420-A2 PEPTIDES THAT BLOCK THE BINDING OF IGG TO FCRN SYNTONIX PHARMACEUTICALS, INC. (US) 2007-08-30 WO disclosed
EP-1516184-B1 Cell-selective delivery system CEPEP II AB (SE) 2007-08-01 EP disclosed
WO-2006017619-A2 RECEPTOR-BINDING CYCLIC PEPTIDES AND METHODS OF USE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-02-16 WO disclosed
US-20060029544-A1 Receptor-binding cyclic peptides and methods of use THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) 2006-02-09 US disclosed
EP-1516184-A2 CELL PENETRATING PEPTIDES CePeP AB (SE) 2005-03-23 EP disclosed
WO-2003106491-A2 CELL PENETRATING PEPTIDES CEPEP AB (SE) 2003-12-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254831-A1 PEPTIDES THAT BLOCK THE BINDING OF IgG to FcRn FCGRT, FCGR3B, FCGR1A GRIA2 741/4885KDM4E 4111/4885ALDH1A1 4835/4885
US-20060029544-A1 Receptor-binding cyclic peptides and methods of use ITGB3, ITGB5, ITGA5 GRIA2 991/4885KDM4E 3616/4885ALDH1A1 4662/4885
US-20080234183-A1 Cell Penetrating Peptides VIP, TAP1, CPA3 GRIA2 4066/4885KDM4E 4173/4885ALDH1A1 4877/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.