Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | IDE | P14735 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3849079 | 0.89 | MEN1 (0.39) | MEN1KMT2AMAP4K1IDECLK1 | |
| SCHEMBL3853295 | 0.88 | IDE (0.42) | MEN1KMT2AIDECLK1CCR5 | |
| Hydrochloric Acid SCHEMBL3855245 | 0.86 | MEN1 (0.42) | MEN1KMT2AMAP4K1IDECLK1 | |
| SCHEMBL3848919 | 0.86 | CDK8 (0.43) | IDECDK8NCF1 | |
| SCHEMBL3852729 | 0.85 | ALDH1A1 (0.43) | IDECLK1NCF1MAPTALDH1A1 | |
| SCHEMBL3845627 | 0.85 | DRD2 (0.42) | MEN1KMT2AIDEMAPK1PDGFRB | |
| Hydrochloric Acid SCHEMBL3853823 | 0.84 | CYP46A1 (0.43) | CDK8NCF1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3853045 | 0.84 | MTNR1B (0.46) | MEN1KMT2AIDECLK1MAPT | |
| Hydrochloric Acid SCHEMBL5852245 | 0.84 | ALDH1A1 (0.43) | IDECLK1NCF1MAPTALDH1A1 | |
| SCHEMBL6637162 | 0.84 | NCF1 (0.45) | NCF1ALDH1A1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |