Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | TACR1 | P25103 | 2/20 | 0.45 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3852451 | 0.83 | PLA2G2A (0.49) | ALDH1A1TACR1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL3853352 | 0.81 | ALDH1A1 (0.49) | ALDH1A1HPGDHSD17B10PPARGTACR1 | |
| SCHEMBL3856618 | 0.80 | PPARG (0.51) | ALDH1A1HPGDHSD17B10PPARGTACR1 | |
| SCHEMBL3852015 | 0.80 | PPARG (0.48) | ALDH1A1HPGDHSD17B10PPARGHSD11B1 | |
| SCHEMBL3852371 | 0.78 | CYP11B2 (0.47) | ALDH1A1HPGDHSD17B10PPARGKDM4E | |
| SCHEMBL12715621 | 0.76 | ALDH1A1 (0.41) | ALDH1A1HPGDHSD17B10PPARGTACR1 | |
| SCHEMBL3857040 | 0.75 | PPARG (0.46) | ALDH1A1HPGDHSD17B10PPARGHSD11B1 | |
| SCHEMBL3853394 | 0.75 | PPARG (0.67) | PPARGTBXAS1 | |
| SCHEMBL3853361 | 0.73 | PPARG (0.56) | ALDH1A1HPGDPPARGTBXAS1KDM4E | |
| SCHEMBL28282805 | 0.70 | CCNB2 (0.43) | ALDH1A1HPGDHSD17B10PPARGTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582773-B2 | Substituted phenyl indoles | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-20050070592-A1 | Substituted phenyl indoles | WYETH (US) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070592-A1 | Substituted phenyl indoles | TPH2, IDO2, AANAT | ALDH1A1 423/4885HPGD 1848/4885HSD17B10 2232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.