Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982330 | 0.84 | KMT2A (0.50) | SMN1; SMN2ALDH1A1MAPTKMT2ACES2 | |
| SCHEMBL3862078 | 0.82 | CES2 (0.62) | SMN1; SMN2ALDH1A1MAPTKMT2ACES2 | |
| SCHEMBL1384938 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1MAPTKMT2ACES2 | |
| SCHEMBL3860533 | 0.80 | KMT2A (0.54) | SMN1; SMN2ALDH1A1MAPTKMT2ACES2 | |
| SCHEMBL3953437 | 0.77 | ALDH1A1 (0.73) | SMN1; SMN2ALDH1A1MAPTKMT2ACES2 | |
| SCHEMBL2459083 | 0.77 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1MAPTKMT2ACES2 | |
| SCHEMBL28709131 | 0.77 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1MAPTKMT2ACES2 | |
| SCHEMBL23340458 | 0.76 | CES2 (0.62) | SMN1; SMN2ALDH1A1MAPTKMT2ACES2 | |
| SCHEMBL15665397 | 0.76 | CES2 (0.75) | SMN1; SMN2ALDH1A1MAPTKMT2ACES2 | |
| SCHEMBL3853904 | 0.76 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1MAPTKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585970-B2 | Method of polynucleotide synthesis using modified support | AGILENT TECHNOLOGIES, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7427679-B2 | Precursors for two-step polynucleotide synthesis | AGILENT TECHNOLOGIES, INC. (US) | 2008-09-23 | — | — | US | disclosed |
| US-7417139-B2 | Method for polynucleotide synthesis | AGILENT TECHNOLOGIES, INC. (US) | 2008-08-26 | — | — | US | disclosed |
| US-7385050-B2 | Cleavable linker for polynucleotide synthesis | AGILENT TECHNOLOGIES, INC. (US) | 2008-06-10 | — | — | US | disclosed |
| US-7193077-B2 | Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis | AGILENT TECHNOLOGIES, INC. (US) | 2007-03-20 | — | — | US | disclosed |
| US-20050186580-A1 | Quality control method for array manufacture | AGILENT TECHNOLOGIES, INC. | 2005-08-25 | — | — | US | disclosed |
| US-20050186579-A1 | MALDI-MS analysis of nucleic acids bound to a surface | AGILENT TECHNOLOGIES, INC. | 2005-08-25 | — | — | US | disclosed |
| EP-1512691-A1 | Protecting groups for two-step polynucleotide synthesis | Agilent Technologies Inc (US) | 2005-03-09 | — | — | EP | disclosed |
| US-20050048496-A1 | Method of polynucleotide synthesis using modified support | AGILENT TECHNOLOGIES, INC. | 2005-03-03 | — | — | US | disclosed |
| US-20050048601-A1 | Method for polynucleotide synthesis | REGENTS OF THE UNIVERSITY OF COLORADO, THE | 2005-03-03 | — | — | US | disclosed |
| US-20050049411-A1 | Exocyclic amine triaryl methyl protecting groups in two step polynucleotide synthesis | REGENTS OF THE UNIVERSITY OF COLORADO, THE | 2005-03-03 | — | — | US | disclosed |
| US-20050048497-A1 | Cleavable linker for polynucleotide synthesis | THE REGENTS OF THE UNIVERSITY OF COLORADO | 2005-03-03 | — | — | US | disclosed |
| US-20050049407-A1 | Precursors for two-step polynucleotide synthesis | THE REGENTS OF THE UNIVERSITY OF COLORADO | 2005-03-03 | — | — | US | disclosed |
| EP-1510523-A1 | Precurors for two-step polynucleotide synthesis | Agilent Technologies Inc (US) | 2005-03-02 | — | — | EP | disclosed |
| EP-1510522-A1 | Method of polynucleotide synthesis using modified support | Agilent Technologies Inc (US) | 2005-03-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050048496-A1 | Method of polynucleotide synthesis using modified support | POLN, POLRMT, POLM | SMN1; SMN2 388/4885ALDH1A1 4090/4885MAPT 3620/4885 |
| US-20050048601-A1 | Method for polynucleotide synthesis | POLN, RNGTT, NSUN2 | SMN1; SMN2 652/4885ALDH1A1 4398/4885MAPT 4158/4885 |
| US-20050049407-A1 | Precursors for two-step polynucleotide synthesis | NT5C3B, NSUN2, POLN | SMN1; SMN2 416/4885ALDH1A1 4145/4885MAPT 4124/4885 |
| US-20050048497-A1 | Cleavable linker for polynucleotide synthesis | TYMP, POLN, CPSF1 | SMN1; SMN2 296/4885ALDH1A1 4036/4885MAPT 4176/4885 |
| US-20050049411-A1 | Exocyclic amine triaryl methyl protecting groups in two step polynucleotide synthesis | NT5C3B, RNMT, NSUN2 | SMN1; SMN2 305/4885ALDH1A1 4399/4885MAPT 3856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.