SCHEMBL385879

SCHEMBL385879

[c]1cccc2c(-c3ccccc3)cccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
METAP2 P50579 1/20 0.38
TNF P01375 1/20 0.38
MAP4K4 O95819 1/20 0.37
CSF1R P07333 1/20 0.37
FGFR1 P11362 1/20 0.37
PDGFRA P16234 1/20 0.37
LTK P29376 1/20 0.37
KDR P35968 1/20 0.37
MAPK8 P45983 1/20 0.37
CSNK1A1 P48729 1/20 0.37
LIMK1 P53667 1/20 0.37
CDK5 Q00535 1/20 0.37
ACVR1 Q04771 1/20 0.37
TNK2 Q07912 1/20 0.37
AURKB Q96GD4 1/20 0.37
CLK4 Q9HAZ1 1/20 0.37
DYRK1B Q9Y463 1/20 0.37
PDCD1 Q15116 1/20 0.36
CD274 Q9NZQ7 1/20 0.36
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18317249 0.89 METAP2 (0.36) METAP2TNFMAP4K4CSF1RFGFR1
SCHEMBL533267 0.88 PARP1 (0.35) METAP2TNFMAP4K4CSF1RFGFR1
SCHEMBL2318595 0.85 CYP1A2 (0.32) CYP2A6
SCHEMBL6537119 0.84 EDNRB (0.36) METAP2TNFMAP4K4CSF1RFGFR1
SCHEMBL2452059 0.84 ALDH1A1 (0.36) RAB9ARCE1ALDH1A1HSD17B10HPGD
SCHEMBL352178 0.83
SCHEMBL28745669 0.83 PIK3CD (0.45) TNFRAB9AALDH1A1HSD17B10HPGD
SCHEMBL2448398 0.82 ALDH1A1 (0.34) MAP4K4CSF1RFGFR1PDGFRALTK
SCHEMBL297788 0.81 FOLH1 (0.41) BCL2L1TDP1L3MBTL1KDM4E
SCHEMBL2270433 0.80 ALDH1A1 (0.40) ALDH1A1HSD17B10HPGDCYP2A6MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230337532-A1 TRIAZINE COMPOUND, MATERIAL FOR ORGANIC LIGHT EMITTING DIODE, ELECTRON TRANSPORT MATERIAL FOR ORGANIC LIGHT EMITTING DIODE, AND ORGANIC LIGHT EMITTING DIODE TOSOH CORPORATION (JP) 2023-10-19 US claimed
CN-116348454-A Triazine compound, material for organic electroluminescent element, electron-transporting material for organic electroluminescent element, and organic electroluminescent element 东曹株式会社 2023-06-27 CN claimed
EP-0361341-A2 Therapeutics for aids based on inhibitors of HIV protease MILES INC. (US) 1990-04-04 EP claimed
CN-113039184-B Compound and organic light emitting device comprising the same 株式会社LG化学 2024-07-12 CN disclosed
US-20230337532-A1 TRIAZINE COMPOUND, MATERIAL FOR ORGANIC LIGHT EMITTING DIODE, ELECTRON TRANSPORT MATERIAL FOR ORGANIC LIGHT EMITTING DIODE, AND ORGANIC LIGHT EMITTING DIODE TOSOH CORPORATION (JP) 2023-10-19 US disclosed
CN-116348454-A Triazine compound, material for organic electroluminescent element, electron-transporting material for organic electroluminescent element, and organic electroluminescent element 东曹株式会社 2023-06-27 CN disclosed
WO-2022075219-A1 TRIAZINE COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENTS, ELECTRON TRANSPORT MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENTS, AND ORGANIC ELECTROLUMINESCENT ELEMENT 東ソー株式会社 2022-04-14 WO disclosed
US-11072573-B2 Binaphthyl compounds REUTER CHEMISCHE APPARATEBAU E.K. (DE) 2021-07-27 US disclosed
CN-109311844-B Triazine compound, method for producing same, and organic electroluminescent element containing same as constituent component 东曹株式会社 2021-07-20 CN disclosed
CN-113039184-A Novel compound and organic light emitting device comprising same 株式会社LG化学 2021-06-25 CN disclosed
CN-112912372-A Cyclic azine compound, material for organic electroluminescent element, electron transport material for organic electroluminescent element, and organic electroluminescent element 东曹株式会社 2021-06-04 CN disclosed
US-5210258-A Optically active alpha-naththylalkyl ketones SYNTEX PHARMACEUTICALS INTERNATIONAL LTD. (BM) 1993-05-11 US disclosed
EP-0361341-A2 Therapeutics for aids based on inhibitors of HIV protease MILES INC. (US) 1990-04-04 EP disclosed
US-4912254-A Preparation of α-arylalkanoic acids SYNTEX PHARMACEUTICAL INTERNATIONAL LIMITED (BM) 1990-03-27 US disclosed
EP-0081993-B1 OPTICALLY ACTIVE ALPHA-SUBSTITUTED ARYL KETONES, THEIR PREPARATION AND THEIR USE IN PREPARING ALPHA-ARYLALKANOIC ACIDS SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1988-08-17 EP disclosed
US-4749804-A Preparation of stereoisomers of ketals SYNTEX (U.S.A.) INC. (US) 1988-06-07 US disclosed
US-4605758-A Preparation of α-arylalkanoic acids SYNTEX PHARMACEUTICALS INTERNATIONAL LTD. (BM) 1986-08-12 US disclosed
EP-0081993-A2 Optically active alpha-substituted aryl ketones, their preparation and their use in preparing alpha-arylalkanoic acids SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1983-06-22 EP disclosed
EP-0064394-A1 Manufacture of alpha-arylalkanoic acids and precursors SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1982-11-10 EP disclosed
US-4011332-A RODENTICIDE BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DT) 1977-03-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11072573-B2 Binaphthyl compounds UACA, C9, C1S METAP2 4389/4885TNF 3007/4885MAP4K4 4140/4885
US-20230337532-A1 TRIAZINE COMPOUND, MATERIAL FOR ORGANIC LIGHT EMITTING DIODE, ELECTRON TRANSPORT MATERIAL FOR ORGANIC LIGHT EMITTING DIODE, AND ORGANIC LIGHT EMITTING DIODE ARNT, TPH1, AHR METAP2 2552/4885TNF 2335/4885MAP4K4 3544/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.