Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249714 | 0.87 | TDP1 (0.52) | TDP1ALDH1A1POLBCYP3A4ALOX15 | |
| SCHEMBL4303054 | 0.79 | TDP1 (0.42) | TDP1ALDH1A1GPR35CYP3A4ALOX15 | |
| SCHEMBL10716598 | 0.77 | TDP1 (0.56) | TDP1ALDH1A1POLBGPR35GAA | |
| SCHEMBL29475175 | 0.77 | TDP1 (1.00) | TDP1ALDH1A1POLBGPR35GAA | |
| SCHEMBL57166 | 0.77 | TDP1 (1.00) | TDP1ALDH1A1POLBGPR35GAA | |
| SCHEMBL11838471 | 0.77 | TDP1 (0.48) | TDP1ALDH1A1GPR35HSD17B10MEN1 | |
| SCHEMBL8370815 | 0.76 | TDP1 (0.52) | TDP1ALDH1A1POLBGPR35GAA | |
| SCHEMBL28093598 | 0.75 | TDP1 (0.95) | TDP1ALDH1A1POLBGPR35GAA | |
| SCHEMBL4306587 | 0.74 | TDP1 (0.61) | TDP1ALDH1A1POLBGPR35GAA | |
| SCHEMBL33832 | 0.72 | TDP1 (0.46) | TDP1ALDH1A1GPR35HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 162 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220775-A1 | ENANTIOSELECTIVE PREPARATION OF QUINOLINE DERIVATIVES | LOHSE OLIVIER (FR) | 2012-08-30 | — | — | US | claimed |
| EP-1791820-B1 | ENANTIOSELECTIVE PREPARATION OF QUINOLINE DERIVATIVES | NOVARTIS AG (CH) | 2009-12-02 | — | — | EP | claimed |
| US-20090054653-A1 | ENANTIOSELEKTIVE PREPARATION OF QUINOLINE DERIVATIVE | LOHSE OLIVIER | 2009-02-26 | — | — | US | claimed |
| US-20080312462-A1 | Process for the manufacture of HMG-CoA reductase inhibitory mevalonic acid derivatives | SEDELMEIER GOTTFRIED | 2008-12-18 | — | — | US | claimed |
| CN-101208341-A | Hexarylene and pentarylene tetracarboxylic acid diimides | BASF AG (DE) | 2008-06-25 | — | — | CN | claimed |
| US-20070155970-A1 | PROCESS FOR THE MANUFACTURE OF HMG-COA REDUCTASE INHIBITORY MEVALONIC ACID DERIVATIVES | SEDELMEIER GOTTFRIED | 2007-07-05 | — | — | US | claimed |
| EP-1791820-A2 | ENANTIOSELECTIVE PREPARATION OF QUINOLINE DERIVATIVES | Novartis AG (CH) | 2007-06-06 | — | — | EP | claimed |
| CN-1318412-C | Process for the manufacture of HMG-CoA reductase inhibitory mevalonic acid derivatives | NOVARTIS AG (CH) | 2007-05-30 | — | — | CN | claimed |
| CN-1968927-A | Enantioselektive preparation of quinoline derivative | NOVARTIS AG (CH) | 2007-05-23 | — | — | CN | claimed |
| US-RE39591-E1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2007-04-24 | — | — | US | claimed |
| US-5866549-A | MACROLIDE ANTIBIOTICS | ABBOTT LABORATORIES (US) | 1999-02-02 | — | — | US | claimed |
| WO-1998009978-A1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 1998-03-12 | — | — | WO | claimed |
| US-5338640-A | Alkali-developable; resistance to oxygen etching; multilayer photoresists; photolithographic printing plates | FUJI PHOTO FILM CO., LTD. (JP) | 1994-08-16 | — | — | US | claimed |
| US-5278273-A | Additional polymer | FUJI PHOTO FILM CO., LTD. (JP) | 1994-01-11 | — | — | US | claimed |
| US-5276124-A | Ladder polymers, photoresists, lithographic printing plates | FUJI PHOTO FILM CO., LTD. (JP) | 1994-01-04 | — | — | US | claimed |
| US-5252686-A | Siloxane polymers and positive working light-sensitive compositions comprising the same | FUJI PHOTO FILM CO., LTD. (JP) | 1993-10-12 | — | — | US | claimed |
| US-5216105-A | SILICONE POLYMERS AND POSITIVE WORKING LIGHT-SENSITIVE COMPOSITIONS COMPRISING THE SAME | FUJI PHOTO FILM CO., LTD. (JP) | 1993-06-01 | — | — | US | claimed |
| US-4772534-A | PHOTORESISTS | FUJI PHOTO FILM CO., LTD. (JP) | 1988-09-20 | — | — | US | claimed |
| US-4125619-A | ANTITHROMBOSIS | MITSUBISHI CHEMICAL INDUSTRIES, LTD. (JP) | 1978-11-14 | — | — | US | claimed |
| US-4049645-A | ANTITHROMBOTIC AGENTS | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JA) | 1977-09-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312462-A1 | Process for the manufacture of HMG-CoA reductase inhibitory mevalonic acid derivatives | HMGCR, COASY, DHCR7 | TDP1 4438/4885ALDH1A1 445/4885POLB 2753/4885 |
| US-20070155970-A1 | PROCESS FOR THE MANUFACTURE OF HMG-COA REDUCTASE INHIBITORY MEVALONIC ACID DERIVATIVES | HMGCR, COASY, DHCR7 | TDP1 4632/4885ALDH1A1 523/4885POLB 2811/4885 |
| US-20090054653-A1 | ENANTIOSELEKTIVE PREPARATION OF QUINOLINE DERIVATIVE | HAX1, OPRK1, OPRD1 | TDP1 1997/4885ALDH1A1 258/4885POLB 856/4885 |
| US-20120220775-A1 | ENANTIOSELECTIVE PREPARATION OF QUINOLINE DERIVATIVES | OPRM1, OPRD1, HAX1 | TDP1 2185/4885ALDH1A1 351/4885POLB 655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.