Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.42 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP9 | P14780 | 3/20 | 0.39 |
| ▸ | ADAM8 | P78325 | 3/20 | 0.39 |
| ▸ | BMP1 | P13497 | 11/20 | 0.39 |
| ▸ | MMP12 | P39900 | 2/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1799334 | 0.81 | ADAM17 (0.50) | ADAM17ADAMTS4MMP1ADAMTS1ADAMTS7 | |
| SCHEMBL14470899 | 0.81 | ADAM17 (0.50) | ADAM17ADAMTS4MMP1ADAMTS1ADAMTS7 | |
| SCHEMBL3869291 | 0.80 | ADAM17 (0.49) | ADAM17ADAMTS4MMP1ADAMTS1ADAMTS7 | |
| SCHEMBL4540251 | 0.78 | BMP1 (0.37) | ADAM17ADAMTS4MMP1ADAMTS1ADAMTS7 | |
| SCHEMBL12619375 | 0.77 | ADAM17 (0.49) | ADAM17ADAMTS4MMP1ADAMTS1ADAMTS7 | |
| SCHEMBL1799058 | 0.76 | ADAM17 (0.54) | ADAM17ADAMTS4MMP1ADAMTS1ADAMTS7 | |
| SCHEMBL3874554 | 0.76 | ADAM17 (0.51) | ADAM17ADAMTS4MMP1ADAMTS1ADAMTS7 | |
| SCHEMBL1800584 | 0.75 | ADAM17 (0.49) | ADAM17ADAMTS4MMP1ADAMTS1ADAMTS7 | |
| SCHEMBL4293039 | 0.75 | ADAM17 (0.48) | ADAM17ADAMTS4MMP1ADAMTS1ADAMTS7 | |
| SCHEMBL12619399 | 0.73 | BMP1 (0.40) | ADAM17ADAMTS4MMP1ADAMTS1ADAMTS7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143386-A1 | Human adam-10 inhibitors | EXELIXIS, INC. | 2009-06-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143386-A1 | Human adam-10 inhibitors | ADAM10, ADAM12, CASP10 | ADAM17 4/4885ADAMTS4 45/4885MMP1 366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.