Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11072585 | 1.00 | PRCP (0.43) | PRCPCHRNB2CHRNA4CHRNB4CHRNA2 | |
| SCHEMBL31569538 | 0.89 | PRCP (0.47) | PRCPCHRNB2CHRNA4CHRNB4CHRNA2 | |
| SCHEMBL3133189 | 0.85 | PRCP (0.37) | PRCPCHRNB2CHRNA4CHRNB4CHRNA2 | |
| SCHEMBL3139980 | 0.85 | PRCP (0.37) | PRCPCHRNB2CHRNA4CHRNB4CHRNA2 | |
| Hydrochloric Acid SCHEMBL52335 | 0.84 | PRCP (0.36) | PRCPCHRNB2CHRNA4CHRNB4CHRNA2 | |
| SCHEMBL10152945 | 0.75 | HTR1A (0.42) | CYP19A1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4173013 | 0.74 | CHRNB2 (0.43) | PRCPCHRNB2CHRNA4CHRNB4CHRNA2 | |
| SCHEMBL19292069 | 0.73 | CYP19A1 (0.37) | CHRNB2CHRNA4CYP19A1DRD2DRD1 | |
| SCHEMBL1724425 | 0.73 | PRCP (0.70) | PRCPCHRNB2CHRNA4CHRNB4CHRNA2 | |
| SCHEMBL18634635 | 0.70 | CYP19A1 (0.37) | CYP19A1DRD2TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086063-A1 | VACCINES FOR PREVENTION AND TREATMENT OF ADDICTION | CORNELL UNIVERSITY (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086063-A1 | VACCINES FOR PREVENTION AND TREATMENT OF ADDICTION | CORNELL UNIVERSITY (US) | 2011-04-14 | — | — | US | disclosed |
| WO-2009149252-A1 | VACCINES FOR PREVENTION AND TREATMENT OF ADDICTION | CORNELL UNIVERSITY (US) | 2009-12-10 | — | — | WO | disclosed |
| US-7592454-B2 | Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-22 | — | — | US | disclosed |
| US-20050239768-A1 | Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2005-10-27 | — | — | US | disclosed |
| US-5250537-A | Treating psychoses | SCIOS NOVA INC. (US) | 1993-10-05 | — | — | US | disclosed |
| US-4870180-A | 1,2-dihydro-4-methyl-1-oxo-5H-pyrido(4,3-b)indoles and the process for their synthesis | SANOFI AND CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1989-09-26 | — | — | US | disclosed |
| US-4698444-A | 1,1-bis(p-fluorophenyl)urea | PFIZER INC. (US) | 1987-10-06 | — | — | US | disclosed |
| US-4568748-A | 2-Carbobenzoxy-8-fluoro-5-(p-fluorophenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | PFIZER INC. (US) | 1986-02-04 | — | — | US | disclosed |
| US-4477669-A | Processes and intermediates useful in the preparation of flutroline | PFIZER INC. (US) | 1984-10-16 | — | — | US | disclosed |
| EP-0082658-A2 | Processes and intermediates useful in the preparation of flutroline | PFIZER INC. (US) | 1983-06-29 | — | — | EP | disclosed |
| US-4352807-A | Hexahydro-trans-pyridoindole neuroleptic agents | PFIZER INC. (US) | 1982-10-05 | — | — | US | disclosed |
| US-4267331-A | REDUCTIVE ALKYLATION OF A 5-PHENYL-2,3,4,4A,5,9B-HEXAHYDRO-1H-PYRIDO/4,3-B/INDOLE WITH A REDUCING AGENT AND A 2-HYDROXY-5- OR 6-PHENYLFURAN OR -PYRAN | PFIZER INC. (US) | 1981-05-12 | — | — | US | disclosed |
| US-4252811-A | Hexahydro-trans-pyridoindole neuroleptic agents | PFIZER INC. (US) | 1981-02-24 | — | — | US | disclosed |
| US-4252812-A | TRANQUILIZERS | PFIZER INC. (US) | 1981-02-24 | — | — | US | disclosed |
| US-4224329-A | TRANQUILIZERS | PFIZER INC. (US) | 1980-09-23 | — | — | US | disclosed |
| US-4091102-A | Anti-depressant trans-hexahydropyrido[3,4-b]indoles | ENDO LABORATORIES, INC. (US) | 1978-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086063-A1 | VACCINES FOR PREVENTION AND TREATMENT OF ADDICTION | SLC6A3, CCR5, OPRK1 | PRCP 2332/4885CHRNB2 93/4885CHRNA4 23/4885 |
| US-20050239768-A1 | Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists | HTR1A, HTR7, HTR1D | PRCP 2859/4885CHRNB2 228/4885CHRNA4 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.