Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8541406 | 0.91 | NPC1 (0.64) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL13701694 | 0.83 | KAT6A (0.56) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| Methyl 3-Methoxybenzoate SCHEMBL7469145 | 0.81 | SMN1; SMN2 (0.62) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL9828778 | 0.78 | NPC1 (0.63) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10197594 | 0.78 | LMNA (0.58) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6301076 | 0.77 | NPC1 (0.57) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10806203 | 0.77 | NPC1 (0.61) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13701741 | 0.77 | LMNA (0.60) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL13342147 | 0.77 | HDAC8 (0.67) | NPC1RAB9ASMN1; SMN2KAT6ALMNA | |
| SCHEMBL21249304 | 0.77 | LMNA (0.58) | NPC1RAB9AKMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619082-B2 | Process for the preparation of 3-spiro′cyclohexan-1,3′-′3H!indolin-2′-one! derivatives | SANOFI-AVENTIS (FR) | 2009-11-17 | — | — | US | disclosed |
| EP-1421064-B1 | PROCESS FOR THE PREPARATION OF 3-SPIRO'CYCLOHEXAM-1,3'-'3H!INDOLIN-2'-ONE! DERIVATIVES | SANOFI AVENTIS (FR) | 2005-05-11 | — | — | EP | disclosed |
| US-20040225124-A1 | Process for the preparation of 3-spiro'cyclohexam-1,3'-'3h!indolin-2'-one! derivatives | SANOFI-AVENTIS (FR) | 2004-11-11 | — | — | US | disclosed |
| EP-1421064-A1 | PROCESS FOR THE PREPARATION OF 3-SPIRO'CYCLOHEXAM-1,3'-'3H!INDOLIN-2'-ONE! DERIVATIVES | Sanofi-Aventis (FR) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003011827-A1 | PROCESS FOR THE PREPARATION OF 3-SPIRO'CYCLOHEXAM-1,3'-'3H!INDOLIN-2'-ONE! DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040225124-A1 | Process for the preparation of 3-spiro'cyclohexam-1,3'-'3h!indolin-2'-one! derivatives | AQP1, AQP3, CIAPIN1 | NPC1 1713/4885RAB9A 2018/4885MEN1 823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.