Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 9/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44570 | 0.85 | CNR1 (0.40) | CYP19A1CNR1LMNAKMT2ATP53 | |
| SCHEMBL44344 | 0.85 | TP53 (0.45) | CYP19A1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL44258 | 0.84 | CYP19A1 (0.60) | CYP19A1ALDH1A1MEN1KMT2ACA1 | |
| SCHEMBL38873 | 0.82 | CYP19A1 (0.47) | CYP19A1ALDH1A1NAMPTPIK3CDPIK3CG | |
| SCHEMBL12926166 | 0.82 | PIK3CD (0.41) | CYP19A1ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL44417 | 0.81 | CYP19A1 (0.39) | CYP19A1LMNAMEN1KMT2ATP53 | |
| SCHEMBL44612 | 0.81 | TSHR (0.42) | CYP19A1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL44400 | 0.81 | ALDH1A1 (0.45) | CYP19A1CNR1LMNAALDH1A1KMT2A | |
| SCHEMBL38716 | 0.77 | FBP1 (0.47) | KDM4EALDH1A1NAMPTMAPTPIK3CD | |
| SCHEMBL39342 | 0.75 | CYP19A1 (0.53) | CYP19A1CNR1LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |