Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38873 | 0.85 | CYP19A1 (0.47) | CYP19A1PIK3CDPIK3CGALDH1A1NAMPT | |
| SCHEMBL12926166 | 0.85 | PIK3CD (0.41) | TP53CYP19A1PIK3CDPIK3CGALDH1A1 | |
| SCHEMBL44668 | 0.85 | CYP19A1 (0.56) | TP53CYP19A1PIK3CDPIK3CGALDH1A1 | |
| SCHEMBL44258 | 0.85 | CYP19A1 (0.60) | CYP19A1PIK3CDPIK3CGALDH1A1PKM | |
| SCHEMBL44400 | 0.84 | ALDH1A1 (0.45) | TP53CYP19A1PIK3CDPIK3CGHSD11B1 | |
| SCHEMBL44519 | 0.83 | LMNA (0.42) | TP53HSD11B1ALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL44570 | 0.80 | CNR1 (0.40) | TP53CYP19A1PIK3CDPIK3CGLMNA | |
| SCHEMBL44612 | 0.80 | TSHR (0.42) | CYP19A1PIK3CDPIK3CGALDH1A1SMN1; SMN2 | |
| SCHEMBL38716 | 0.77 | FBP1 (0.47) | PIK3CDPIK3CGALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL22489791 | 0.76 | NAMPT (0.54) | TP53CYP19A1HSD11B1ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |