Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Troclosene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Troclosene SCHEMBL6894267 | 1.00 | APEX1 (0.30) | APEX1 | |
| Troclosene SCHEMBL28991821 | 0.97 | — | — | |
| Troclosene SCHEMBL31099328 | 0.97 | — | — | |
| Troclosene SCHEMBL166386 | 0.97 | APEX1 (0.31) | APEX1 | |
| Troclosene SCHEMBL21745 | 0.94 | APEX1 (0.30) | APEX1 | |
| Troclosene SCHEMBL305053 | 0.94 | APEX1 (0.30) | APEX1 | |
| Troclosene SCHEMBL30616181 | 0.94 | APEX1 (0.30) | APEX1 | |
| Troclosene SCHEMBL531397 | 0.94 | APEX1 (0.30) | APEX1 | |
| Troclosene SCHEMBL9083160 | 0.94 | APEX1 (0.30) | APEX1 | |
| Troclosene SCHEMBL29779771 | 0.94 | APEX1 (0.30) | APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465410-B2 | Solvent-activated reactor | TRUOX, INC. (US) | 2008-12-16 | — | — | US | claimed |
| US-20060197056-A1 | Water soluble mixture that generates chlorine dioxide including chlorite donor and a free halogen donor, forms gel when exposed to the main solvent that encloses the reactants, restricts reactant diffusion, and prevents contact with solvent; ClO2 released through colloidal gel wall at a controlled rate | TRUOX, INC. | 2006-09-07 | — | — | US | claimed |
| WO-2006020247-A2 | A SOLVENT-ACTIVATED REACTOR | TRUOX, INC. (US) | 2006-02-23 | — | — | WO | claimed |
| US-20060013751-A1 | Solvent-activated reactor | TRUOX, INC. | 2006-01-19 | — | — | US | claimed |
| US-20040135116-A1 | Massive bodies containing free halogen source for producing highly converted solutions of chlorine dioxide | ENGELHARD CORPORATION | 2004-07-15 | — | — | US | claimed |
| US-6699404-B2 | TABLET, FOR PRODUCING A SOLUTION OF CHLORINE DIOXIDE WHEN THE MASSIVE BODY IS ADDED TO LIQUID WATER | ENGELHARD CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-20030080317-A1 | Massive bodies containing free halogen source for producing highly converted solutions of chlorine dioxide | ENGELHARD CORPORATION | 2003-05-01 | — | — | US | claimed |
| WO-2013036601-A1 | USE OF MOSS TO REDUCE DISINFECTION BY-PRODUCTS IN WATER TREATED WITH DISINFECTANTS | EMBRO CORPORATION (US) | 2013-03-14 | — | — | WO | disclosed |
| CN-101448863-A | Polyvinyl alcohol films with improved resistance to oxidizing chemicals | CELANESE INT CORP (US) | 2009-06-03 | — | — | CN | disclosed |
| US-7534368-B2 | Water soluble mixture that generates chlorine dioxide including chlorite donor and a free halogen donor, forms gel when exposed to the main solvent that encloses the reactants, restricts reactant diffusion, and prevents contact with solvent; ClO2 released through colloidal gel wall at a controlled rate | TRUOX, INC. (US) | 2009-05-19 | — | — | US | disclosed |
| US-7514019-B2 | Water soluble mixture that generates chlorine dioxide including chlorite donor and polymeric that forms a gel when exposed to the main solvent that encloses the reactants, restricts reactant diffusion, and prevents contact with solvent; ClO2 released through colloidal gel wall at a controlled rate | TRUOX, INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-7465410-B2 | Solvent-activated reactor | TRUOX, INC. (US) | 2008-12-16 | — | — | US | disclosed |
| US-20060197056-A1 | Water soluble mixture that generates chlorine dioxide including chlorite donor and a free halogen donor, forms gel when exposed to the main solvent that encloses the reactants, restricts reactant diffusion, and prevents contact with solvent; ClO2 released through colloidal gel wall at a controlled rate | TRUOX, INC. | 2006-09-07 | — | — | US | disclosed |
| US-20060013751-A1 | Solvent-activated reactor | TRUOX, INC. | 2006-01-19 | — | — | US | disclosed |
| US-20060014872-A1 | Protective composition that allows in-situ generation of permeation channels therein | TRUOX, INC. | 2006-01-19 | — | — | US | disclosed |
| US-20050155936-A1 | Halogen-enhanced oxidizing composition | TRUOX, INC. | 2005-07-21 | — | — | US | disclosed |
| EP-0291097-B1 | METHOD OF PREPARING SPHERICAL GRANULES AND TABLETS OF A SOLID CHLORINATING AGENT | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1991-12-04 | — | — | EP | disclosed |
| EP-0291097-A2 | Method of preparing spherical granules and tablets of a solid chlorinating agent | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1988-11-17 | — | — | EP | disclosed |
| US-4329431-A | Instant culture media and method of sterilizing same | YOUSSEF KAMAL A | 1982-05-11 | — | — | US | disclosed |
| US-4248971-A | ADDING CHLORINE-LIBERATING COMPOUND, WITHOUT AUTOCLAVING | YOUSSEF KAMAL A | 1981-02-03 | — | — | US | disclosed |