Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | PFKFB3 | Q16875 | 5/20 | 0.47 |
| ▸ | PFKFB4 | Q16877 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878752 | 0.89 | CXCR3 (0.46) | PFKFB3PFKFB4MEN1KMT2AL3MBTL1 | |
| SCHEMBL3879417 | 0.85 | PFKFB3 (0.61) | PFKFB3PFKFB4MEN1KMT2AL3MBTL1 | |
| SCHEMBL3874736 | 0.85 | HSD11B1 (0.54) | NPC1RAB9APFKFB3PFKFB4MEN1 | |
| SCHEMBL3886211 | 0.83 | PFKFB4 (0.64) | RAB9APFKFB3PFKFB4F10CMA1 | |
| SCHEMBL3874981 | 0.80 | PFKFB4 (0.51) | NPC1RAB9APFKFB3PFKFB4ALDH1A1 | |
| SCHEMBL3873199 | 0.80 | PFKFB4 (0.48) | PFKFB3PFKFB4L3MBTL1ALDH1A1F10 | |
| SCHEMBL3874308 | 0.80 | PFKFB4 (0.45) | PFKFB3PFKFB4F10LMNACMA1 | |
| SCHEMBL3881153 | 0.79 | ALDH1A1 (0.51) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL3886517 | 0.79 | PFKFB3 (0.53) | RAB9APFKFB3PFKFB4CMA1 | |
| SCHEMBL3881241 | 0.78 | LSS (0.43) | PFKFB3PFKFB4MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814846-B1 | 11BETA-HSD1 INHIBITORS | EVOTEC AG (DE) | 2009-04-08 | — | — | EP | disclosed |
| US-20090069323-A1 | 11beta-hsdi inhibitors | EVOTEC AG (DE) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069323-A1 | 11beta-hsdi inhibitors | HSD3B1, HSD3B2, HSD11B1 | NPC1 599/4885RAB9A 4300/4885PFKFB3 1134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.