Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869989 | 0.94 | KCNH2 (0.56) | KCNH2GPR119CYP3A4SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL385338 | 0.92 | CHEK2 (0.49) | SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL387402 | 0.92 | SIGMAR1 (0.56) | KCNH2SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL387100 | 0.92 | CHEK2 (0.48) | SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL384634 | 0.92 | CHEK2 (0.49) | KCNH2GPR119SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL387452 | 0.91 | SIGMAR1 (0.46) | KCNH2GPR119SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL387450 | 0.90 | MAOA (0.49) | CHRM4HRH3SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL384683 | 0.90 | SIGMAR1 (0.48) | KCNH2GPR119SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL387343 | 0.89 | FAAH (0.48) | KCNH2GPR119SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL387548 | 0.88 | KCNH2 (0.46) | KCNH2GPR119SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077812-A1 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | FANG JING (US) | 2012-03-29 | — | — | US | disclosed |
| US-8101634-B2 | Bicyclic compounds and use as antidiabetics | GLAXOSMITHKLINE LLC (US) | 2012-01-24 | — | — | US | disclosed |
| EP-2325182-A1 | Bicyclic compounds and use as antidiabetics | Glaxosmithkline LLC (US) | 2011-05-25 | — | — | EP | disclosed |
| US-20100029650-A1 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITH KLINE BEECHAM CORPORATION a corporation | 2010-02-04 | — | — | US | disclosed |
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077812-A1 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | GPR119, GOT2, PC | KCNH2 2919/4885GPR119 1/4885CYP3A4 570/4885 |
| US-20100029650-A1 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | GPR119, GOT2, PC | KCNH2 2919/4885GPR119 1/4885CYP3A4 570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.