Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | KDM4A | O75164 | 2/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4B | O94953 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.33 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3874792 | 0.90 | KDM4C (0.43) | HDAC6HDAC1KDM4AKDM5BKDM5A | |
| Potassium Ion SCHEMBL3873536 | 0.81 | KDM4A (0.45) | HDAC6HDAC1KDM4AKDM5BKDM5A | |
| Potassium Ion SCHEMBL3877708 | 0.78 | KDM5B (0.52) | HDAC6HDAC1KDM4AKDM5BKDM5A | |
| Potassium Ion SCHEMBL3885749 | 0.77 | KDM5B (0.43) | KDM4AKDM5BKDM5AKDM4CKDM4B | |
| Potassium Ion SCHEMBL3874287 | 0.77 | KDM5B (0.45) | HDAC6KDM4AKDM5BKDM5AKDM4C | |
| Potassium Ion SCHEMBL3886555 | 0.75 | KDM4C (0.48) | HDAC6HDAC1KDM4AKDM5BKDM4C | |
| Potassium Ion SCHEMBL3879744 | 0.75 | CYP19A1 (0.47) | HDAC1HDAC2HDAC8 | |
| Potassium Ion SCHEMBL3874312 | 0.74 | KDM4A (0.55) | KDM4AKDM5BMAPTKDM4BKDM5C | |
| Potassium Ion SCHEMBL3882943 | 0.73 | HDAC1 (0.51) | HDAC6HDAC1HDAC2HDAC8MEN1 | |
| SCHEMBL3881934 | 0.71 | KDM5A (0.55) | KDM4AKDM5BKDM5AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910305-B1 | IMIDAZOLE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK PATENT GMBH (DE) | 2009-08-26 | — | — | EP | claimed |