Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 5/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 5/20 | 0.35 |
| ▸ | CTSC | P53634 | 3/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CTSH | P09668 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | CPA1 | P15085 | 1/20 | 0.32 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877226 | 0.86 | SMYD3 (0.37) | PRSS1PRSS2PRSS3TPSAB1CTSC | |
| SCHEMBL3881029 | 0.85 | DPP4 (0.33) | HDAC4 | |
| SCHEMBL5814696 | 0.83 | PRSS1 (0.33) | PRSS1PRSS2PRSS3TPSAB1F2 | |
| SCHEMBL5396687 | 0.83 | PRSS1 (0.34) | PRSS1PRSS2PRSS3TPSAB1CTSC | |
| SCHEMBL13937593 | 0.82 | CTSS (0.46) | CTSKCTSBCTSS | |
| SCHEMBL3870371 | 0.79 | HDAC1 (0.44) | CTSCHDAC4HDAC6CTSKCYP1A2 | |
| SCHEMBL3871942 | 0.79 | DGAT1 (0.35) | CTSCCTSKCTSBCTSS | |
| SCHEMBL3870467 | 0.78 | MMP1 (0.43) | CTSCKLKB1HDAC4HDAC6CTSK | |
| SCHEMBL3869390 | 0.77 | CTSK (0.36) | CTSCCTSKCYP1A2CYP3A4CTSH | |
| SCHEMBL3969452 | 0.75 | OPRK1 (0.37) | CTSCHDAC6CTSKCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482448-B2 | Compounds and compositions as cathepsin inhibitors | AVENTIS PHARMACEUTICALS INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-20060189657-A1 | Novel compounds and compositions as cathepsin inhibitors | AVENTIS PHARMACEUTICALS INC. (US) | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189657-A1 | Novel compounds and compositions as cathepsin inhibitors | CTSB, CTSS, CTSK | PRSS1 32/4885PRSS2 34/4885PRSS3 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.