Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7744211 | 0.71 | TAAR1 (0.44) | PDE3BPDE3ASNCA | |
| SCHEMBL5600491 | 0.67 | HTR2C (0.45) | — | |
| SCHEMBL11323878 | 0.65 | — | — | |
| SCHEMBL28376107 | 0.65 | SNCA (0.43) | PDE3BPDE3ASNCA | |
| Hydrochloric Acid SCHEMBL6996221 | 0.64 | — | — | |
| SCHEMBL27756123 | 0.63 | IMPDH2 (0.37) | — | |
| SCHEMBL26070491 | 0.62 | P2RX3 (0.47) | — | |
| SCHEMBL16824548 | 0.62 | MAOA (0.41) | — | |
| SCHEMBL7136350 | 0.62 | TRPV4 (0.34) | — | |
| SCHEMBL28286565 | 0.62 | MAOA (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592356-B2 | Triazoles as farnesyl transferase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-09-22 | — | — | US | disclosed |
| US-7511061-B2 | Triazoles as farnesyl transferase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-31 | — | — | US | disclosed |
| US-20080103150-A1 | Triazoles as Farnesyl Transferase Inhibitors | SAHA ASHIS K | 2008-05-01 | — | — | US | disclosed |
| EP-1232147-B1 | TRIAZOLES AS FARNESYL TRANSFERASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-04-02 | — | — | EP | disclosed |
| US-7049324-B1 | Triazoles as farnesyl transferase inhibitors | JANSSEN PHARMACEUTICA INC. | 2006-05-23 | — | — | US | disclosed |
| US-20050234117-A1 | Triazoles as farnesyl transferase inhibitors | SAHA ASHIS K | 2005-10-20 | — | — | US | disclosed |
| EP-1232147-A1 | TRIAZOLES AS FARNESYL TRANSFERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-08-21 | — | — | EP | disclosed |
| WO-2001036395-A1 | TRIAZOLES AS FARNESYL TRANSFERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-05-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234117-A1 | Triazoles as farnesyl transferase inhibitors | CYP7A1, HSD3B1, CES1 | PDE3B 3450/4885PDE3A 3485/4885SNCA 4851/4885 |
| US-20080103150-A1 | Triazoles as Farnesyl Transferase Inhibitors | CYP7A1, HSD3B1, CES1 | PDE3B 3456/4885PDE3A 3490/4885SNCA 4852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.