Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.41 |
| ▸ | KDM6B | O15054 | 2/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10413385 | 0.79 | KDM4C (0.45) | KDM4CKDM6BKDM4DKDM4EMEN1 | |
| SCHEMBL24144744 | 0.78 | NFE2L2 (0.40) | PTGS1PTGS2CA12CA2CA9 | |
| SCHEMBL1648325 | 0.77 | KDM4E (0.49) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL29276912 | 0.76 | CA12 (0.49) | PTGS1PTGS2CA12CA2CA9 | |
| SCHEMBL9470357 | 0.74 | HSD11B1 (0.46) | KDM4EMEN1ALDH1A1KMT2ATDP1 | |
| SCHEMBL2317318 | 0.73 | RAB9A (0.42) | KDM4EALDH1A1CA12CA2CA9 | |
| SCHEMBL668446 | 0.73 | KDM4C (0.49) | KDM4CKDM6BKDM4DKDM4EMEN1 | |
| SCHEMBL30465506 | 0.73 | KDM4C (0.49) | KDM4CKDM6BKDM4DKDM4EMEN1 | |
| SCHEMBL28721905 | 0.73 | PTGS1 (0.36) | KDM4CKDM4APTGS1PTGS2CA12 | |
| SCHEMBL29397704 | 0.73 | PTGS1 (0.36) | KDM4CKDM4APTGS1PTGS2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111400-A1 | PYRIDINE COMPOUNDS AND THEIR USE AS P2Y12 ANTAGONISTS. | AstraZeneca AB (SE) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008085117-A1 | PYRIDINE COMPOUNDS AND THEIR USE AS P2Y12 ANTAGONISTS. | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008085119-A1 | NEW PYRIDINE ANALOGUES VIII 518 | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |