Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.42 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877272 | 0.85 | TAS1R3 (0.45) | CDK9SLC6A1SLC6A11TSHRLMNA | |
| SCHEMBL6203700 | 0.83 | KDM4E (0.45) | KMT2ASLC6A1SLC6A11TSHRLMNA | |
| SCHEMBL16333620 | 0.82 | KMT2A (0.52) | NPC1RAB9AKMT2AKCNH2ALOX5 | |
| SCHEMBL2323451 | 0.81 | HSD11B1 (0.49) | KMT2ASLC6A1SLC6A11TSHRLMNA | |
| SCHEMBL2449552 | 0.80 | ULK1 (0.56) | NPC1RAB9AKMT2ACDK9 | |
| Hydrochloric Acid SCHEMBL5478791 | 0.80 | HSD11B1 (0.48) | KMT2ASLC6A1SLC6A11TSHRLMNA | |
| SCHEMBL6203499 | 0.79 | HDAC1 (0.48) | — | |
| SCHEMBL6203532 | 0.79 | HDAC1 (0.48) | — | |
| SCHEMBL6204321 | 0.79 | HDAC1 (0.48) | — | |
| Hydrochloric Acid SCHEMBL193349 | 0.79 | ULK1 (0.55) | NPC1RAB9AKMT2ACDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089386-A2 | OXAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008056259-A2 | OXAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2008-05-15 | — | — | WO | disclosed |