Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CFTR | P13569 | 2/20 | 0.49 |
| ▸ | GOPC | Q9HD26 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2847597 | 0.85 | HDAC4 (0.70) | SMN1; SMN2POLBMEN1LMNAMAPT | |
| SCHEMBL4618312 | 0.84 | POLB (0.67) | SMN1; SMN2POLBMEN1LMNAKMT2A | |
| SCHEMBL14284024 | 0.81 | SMN1; SMN2 (0.55) | KDM4ESMN1; SMN2POLBCFTRGOPC | |
| SCHEMBL4534187 | 0.81 | SMN1; SMN2 (0.58) | KDM4ESMN1; SMN2CFTRGOPCSLC6A2 | |
| SCHEMBL4529929 | 0.81 | ALDH1A1 (0.55) | KDM4ESMN1; SMN2KMT2ACFTRGOPC | |
| SCHEMBL27592790 | 0.80 | RAB9A (0.51) | KDM4ESMN1; SMN2POLBKMT2ANAMPT | |
| Hydrochloric Acid SCHEMBL27749671 | 0.79 | RAB9A (0.50) | KDM4ESMN1; SMN2POLBKMT2ANAMPT | |
| SCHEMBL3735137 | 0.79 | ROCK2 (0.47) | KDM4ESMN1; SMN2POLBLMNACFTR | |
| SCHEMBL2198036 | 0.78 | ALDH1A1 (0.55) | SMN1; SMN2LMNACFTRGOPCSLC6A2 | |
| SCHEMBL29937752 | 0.78 | ALDH1A1 (0.55) | SMN1; SMN2LMNACFTRGOPCSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013209-A2 | PYRAZOLO-TETRAHYDROPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007122591-A2 | PYRAZOLO-TETRAHYDRO PYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-11-01 | — | — | WO | disclosed |