SCHEMBL3889190

SCHEMBL3889190

Cc1cc(Sc2sc(-c3ccccc3C(F)(F)F)nc2C)ccc1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 3/20 0.36
TRPM8 Q7Z2W7 2/20 0.36
TRPV1 Q8NER1 1/20 0.36
PPARD Q03181 11/20 0.35
PPARA Q07869 4/20 0.35
PPARG P37231 2/20 0.35
MEN1 O00255 2/20 0.35
MAPT P10636 2/20 0.35
KMT2A Q03164 2/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP3A4 P08684 1/20 0.35
HPGD P15428 1/20 0.35
ALOX15 P16050 1/20 0.35
HSD17B10 Q99714 1/20 0.35
S1PR1 P21453 3/20 0.33
PDE2A O00408 1/20 0.32
PDE10A Q9Y233 1/20 0.32
GAA P10253 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3954496 0.85 PPARD (0.50) PPARDPPARAPPARGMEN1MAPT
SCHEMBL3889186 0.83 PPARD (0.49) PPARDPPARAPPARG
SCHEMBL5482065 0.76 PPARD (0.52) TRPA1TRPM8TRPV1PPARDPPARA
SCHEMBL3965973 0.71 PPARD (0.41) PPARDPPARAPPARGMEN1MAPT
SCHEMBL3954490 0.68 PPARD (0.68) PPARDPPARAPPARGMEN1MAPT
SCHEMBL2166925 0.65 PPARD (0.50) TRPA1TRPM8TRPV1PPARDPPARA
SCHEMBL2411136 0.65 ADRA2A (0.39) PPARG
SCHEMBL15142266 0.65 PPARD (0.55) PPARDPPARAPPARGMEN1MAPT
SCHEMBL3962325 0.64 PPARD (0.75) PPARDPPARAPPARG
SCHEMBL900779 0.62 ALDH1A1 (0.47) TRPA1TRPM8TRPV1MEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090264660-A1 PROCESS FOR ALKYL ARYL SULFIDE DERIVATIVES AND NEW SULFIDE COMPOUNDS Kang, Heonjoong (KR) 2009-10-22 US claimed
EP-1812386-A1 PROCESS FOR ALKYL ARYL SULFIDE DERIVATIVES AND NEW SULFIDE COMPOUNDS Kang, Heonjoong (KR) 2007-08-01 EP claimed
WO-2006043797-A1 PROCESS FOR ALKYL ARYL SULFIDE DERIVATIVES AND NEW SULFIDE COMPOUNDS KANG HEONJOONG (KR) 2006-04-27 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090264660-A1 PROCESS FOR ALKYL ARYL SULFIDE DERIVATIVES AND NEW SULFIDE COMPOUNDS TST, ARSA, STS TRPA1 46/4885TRPM8 1348/4885TRPV1 1522/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.