Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 17/20 | 0.60 |
| ▸ | IDO1 | P14902 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | HTR1B | P28222 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087602 | 1.00 | SLC6A4 (0.60) | SLC6A4IDO1SLC6A2SLC6A3HTR1A | |
| SCHEMBL6086690 | 1.00 | SLC6A4 (0.60) | SLC6A4IDO1SLC6A2SLC6A3HTR1A | |
| SCHEMBL5792377 | 0.92 | SLC6A4 (0.63) | SLC6A4IDO1SLC6A2SLC6A3HTR1A | |
| Ethylene SCHEMBL7484426 | 0.90 | SLC6A4 (0.60) | SLC6A4IDO1SLC6A2SLC6A3HTR1A | |
| SCHEMBL6637435 | 0.82 | IDO1 (0.58) | SLC6A4IDO1SLC6A2SLC6A3HTR1A | |
| SCHEMBL6088540 | 0.80 | IKBKB (0.44) | SLC6A4IDO1SLC6A2SLC6A3HTR1A | |
| SCHEMBL6088026 | 0.80 | IDO1 (0.56) | SLC6A4IDO1SLC6A2SLC6A3HTR1A | |
| SCHEMBL3886137 | 0.80 | IDO1 (0.56) | SLC6A4IDO1SLC6A2SLC6A3HTR1A | |
| SCHEMBL6087784 | 0.80 | IDO1 (0.56) | SLC6A4IDO1HTR1AHTR1BHTR2A | |
| SCHEMBL6090803 | 0.80 | IDO1 (0.56) | SLC6A4IDO1SLC6A2SLC6A3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488751-B2 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH (US) | 2009-02-10 | — | — | US | disclosed |
| US-20060160881-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH (US) | 2006-07-20 | — | — | US | disclosed |
| US-20060148881-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-Benzodioxan | WYETH (US) | 2006-07-06 | — | — | US | disclosed |
| US-7049314-B2 | Sexual disorders; antidepressants; attention deficit hyperactivity, obsessive-compulsive, and/or post-traumatic stress disorder; drug abuse and addiction | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-23 | — | — | US | disclosed |
| US-7041697-B2 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH (US) | 2006-05-09 | — | — | US | disclosed |
| EP-1537103-A1 | ANTIDEPRESSANT CYCLOALKYLAMINE DERIVATES OF 2,3-DIHYDRO-1,4-BENZODIOXAN | Wyeth (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040127543-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH | 2004-07-01 | — | — | US | disclosed |
| US-20040077705-A1 | Cyclopentyl indole derivatives | BRISTOL-MYERS SQUIBB COMPANY | 2004-04-22 | — | — | US | disclosed |
| WO-2004026236-A2 | CYCLOPENTYL INDOLE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |
| WO-2004024723-A1 | ANTIDEPRESSANT CYCLOALKYLAMINE DERIVATIVES OF 2,3-DIHYDRO-1,4-BENZODIOXAN | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160881-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | HTR5A, OPRD1, DRD2 | SLC6A4 66/4885IDO1 1320/4885SLC6A2 68/4885 |
| US-20040077705-A1 | Cyclopentyl indole derivatives | HTR5A, TPH1, TPH2 | SLC6A4 11/4885IDO1 25/4885SLC6A2 40/4885 |
| US-20040127543-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | HTR5A, OPRD1, TAAR5 | SLC6A4 61/4885IDO1 835/4885SLC6A2 71/4885 |
| US-20060148881-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-Benzodioxan | HTR5A, OPRD1, DRD2 | SLC6A4 66/4885IDO1 1320/4885SLC6A2 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.