Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3890069 | 0.91 | MAOA (0.60) | DPP4SLC6A4SLC6A2SLC6A3MAOA | |
| SCHEMBL3891504 | 0.78 | SLC6A3 (0.63) | DPP4SLC6A4SLC6A2SLC6A3MAOA | |
| SCHEMBL16515960 | 0.78 | DPP4 (0.53) | DPP4SLC6A4SLC6A2SLC6A3MAOA | |
| SCHEMBL497930 | 0.77 | DPP4 (0.63) | DPP4SLC6A4SLC6A2SLC6A3MAOA | |
| SCHEMBL1152119 | 0.77 | DPP4 (0.63) | DPP4SLC6A4SLC6A2SLC6A3MAOA | |
| SCHEMBL6409381 | 0.77 | DPP4 (0.63) | DPP4SLC6A4SLC6A2SLC6A3MAOA | |
| SCHEMBL9330358 | 0.77 | DPP4 (0.63) | DPP4SLC6A4SLC6A2SLC6A3MAOA | |
| SCHEMBL294582 | 0.77 | DPP4 (1.00) | DPP4SLC6A4SLC6A2SLC6A3MAOA | |
| SCHEMBL19382461 | 0.77 | DPP4 (0.63) | DPP4SLC6A4SLC6A2SLC6A3MAOA | |
| SCHEMBL8122483 | 0.77 | DPP4 (0.63) | DPP4SLC6A4SLC6A2SLC6A3MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105722831-B | Pyridazinone compound and application thereof | 艾丽奥斯生物制药有限公司 | 2019-08-06 | — | — | CN | disclosed |
| US-10364226-B2 | Pyridazinone compounds and uses thereof | ALIOS BIOPHARMA, INC. (US) | 2019-07-30 | — | — | US | disclosed |
| EP-3030549-B1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA INC (US) | 2019-02-20 | — | — | EP | disclosed |
| US-20160221963-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | Janssen Pharmaceuticals, Inc. | 2016-08-04 | — | — | US | disclosed |
| CN-105722831-A | Pyridazinone compounds and uses thereof | 艾丽奥斯生物制药有限公司 | 2016-06-29 | — | — | CN | disclosed |
| EP-3030549-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | Alios Biopharma, Inc. (US) | 2016-06-15 | — | — | EP | disclosed |
| WO-2015038660-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. (US) | 2015-03-19 | — | — | WO | disclosed |
| US-7498344-B2 | Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same | ASUBIO PHARMA CO., LTD. (JP) | 2009-03-03 | — | — | US | disclosed |
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| EP-0867183-B1 | ARYLPIPERIDINOL AND ARYLPIPERIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2004-10-06 | — | — | EP | disclosed |
| US-20040186138-A1 | Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same | DAIICHI SUNTORY PHARMA CO., LTD. | 2004-09-23 | — | — | US | disclosed |
| US-6706734-B2 | ANTIISCHEMIC AGENTS; ANTICONVULSANTS; HEADACHES | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2004-03-16 | — | — | US | disclosed |
| US-20030130312-A1 | Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same | ASUBIO PHARMA CO., LTD. (JP) | 2003-07-10 | — | — | US | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |
| US-6455549-B1 | ANTIEPILEPTIC, ANTIISCHEMIC, AND ANTIMIGRAINE AGENTS; CALCIUM OVELOAD SUPPRESSANTS | SUNTORY LIMITED (JP) | 2002-09-24 | — | — | US | disclosed |
| US-6048876-A | ANTICONVULSANTS; ANTIEPILEPIC AGENT | SUNTORY LIMITED (JP) | 2000-04-11 | — | — | US | disclosed |
| EP-0867183-A1 | ARYLPIPERIDINOL AND ARYLPIPERIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1998-09-30 | — | — | EP | disclosed |
| EP-0755923-A1 | AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160221963-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | PDXK, PNPO, PLPBP | DPP4 41/4885SLC6A4 3240/4885SLC6A2 4265/4885 |
| US-20030130312-A1 | Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same | KCNH1, KCNH2, NPY1R | DPP4 2185/4885SLC6A4 1503/4885SLC6A2 2045/4885 |
| US-10364226-B2 | Pyridazinone compounds and uses thereof | PDXK, PNPO, PLPBP | DPP4 41/4885SLC6A4 3240/4885SLC6A2 4265/4885 |
| US-20040186138-A1 | Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same | KCNH1, KCNH2, NPY1R | DPP4 2185/4885SLC6A4 1503/4885SLC6A2 2045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.