SCHEMBL389037

SCHEMBL389037

CN(CCOc1ccc(C[C@H](OCC(F)(F)F)C(=O)O)cc1)c1nc2ccccc2o1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 1.00
PPARA Q07869 2/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL389036 1.00 PPARG (1.00) PPARGPPARA
SCHEMBL30475600 1.00 PPARG (1.00) PPARGPPARA
SCHEMBL8007402 0.92 PPARG (0.86) PPARGPPARA
SCHEMBL7815152 0.92 PPARG (0.84) PPARGPPARA
SCHEMBL7997939 0.92 PPARG (0.84) PPARGPPARA
SCHEMBL9267167 0.89 PPARG (0.86) PPARGPPARA
SCHEMBL10211510 0.89 PPARG (0.86) PPARGPPARA
SCHEMBL13588984 0.89 PPARG (1.00) PPARGPPARA
SCHEMBL7822831 0.89 PPARG (1.00) PPARGPPARA
SCHEMBL7823360 0.89 PPARG (0.85) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 344 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4743083-A1 METHODS OF TREATING FIBROTIC LIVER DISEASES OR CONDITIONS WITH INDEGLITAZAR Pleiogenix Inc. (US) 2026-05-20 EP disclosed
WO-2026102082-A1 ALKYLPHENYL SUBSTITUTED COMPOUNDS, COMPOSITIONS AND METHODS OF USE DEEP APPLE THERAPEUTICS, INC. (US) 2026-05-15 WO disclosed
US-20260132164-A1 PNU ANTHRACYCLINE DERIVATIVES AND METHODS OF USE THEREOF MERCK SHARP & DOHME LLC (US) 2026-05-14 US disclosed
US-20260132119-A1 Alkylphenyl Substituted Compounds, Compositions and Methods of Use DEEP APPLE THERAPEUTICS, INC. (US) 2026-05-14 US disclosed
US-20260130872-A1 Substituted Bicyclic Compounds, Compositions and Methods of Use DEEP APPLE THERAPEUTICS, INC. (US) 2026-05-14 US disclosed
WO-2026088071-A1 SUBSTITUTED FUSED HETEROARYL LACTAM COMPOUNDS PFIZER INC. (US) 2026-04-30 WO disclosed
EP-4076459-B1 PRMT5 INHIBITORS MERCK SHARP & DOHME LLC (US) 2026-04-29 EP disclosed
US-12611401-B2 Combinations comprising benzodioxol as GLP-1R agonists for use in the treatment of NASH/NAFLD and related diseases PFIZER INC. (US) 2026-04-28 US disclosed
US-12595248-B2 PRMT5 inhibitors MERCK SHARP & DOHME LLC (US) 2026-04-07 US disclosed
US-12595262-B2 PRMT5 inhibitors MERCK SHARP & DOHME LLC (US) 2026-04-07 US disclosed
US-6444816-B1 DIETETICS, ANTICHOLESTEROL AGENTS, ANTIDIABETIC AGENTS DR. REDDY'S RESEARCH FOUNDATION (IN) 2002-09-03 US disclosed
WO-2002062799-A1 ARYL SUBSTITUTED ALKYLCARBOXYLIC ACIDS AS HYPOCHOLESTEROLEMIC AGENTS DR. REDDY'S LABORATORIES LTD. (IN) 2002-08-15 WO disclosed
US-20020103215-A1 New monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them DR. REDDY'S RESEARCH FOUNDATION & REDDY-CHEMINOR, INC. 2002-08-01 US disclosed
US-20020082258-A1 Novel bicyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them DR. REDDY'S RESEARCH FOUNDATION & REDDY- CHEMINOR, INC. 2002-06-27 US disclosed
US-6369067-B1 Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them DR. REDDY'S RESEARCH FOUNDATION (IN) 2002-04-09 US disclosed
US-6265401-B1 ANTIDIABETIC AGENTS REDDY-CHEMINOR, INC. 2001-07-24 US disclosed
US-6166049-A Use of an antagonist of PPARα and PPARγ for the treatment of syndrome X SMITHKLINE BEECHAM P.L.C. (GB) 2000-12-26 US disclosed
EP-0879053-A1 USE OF AN ANTAGONIST OF PPAR-ALPHA AND PPAR-GAMMA FOR THE TREATMENT OF SYNDROM X SMITHKLINE BEECHAM PLC (GB) 1998-11-25 EP disclosed
WO-1997025042-A1 USE OF AN AGONIST OF PPAR-ALPHA AND PPAR-GAMMA FOR THE TREATMENT OF SYNDROM X SMITHKLINE BEECHAM P.L.C. (GB) 1997-07-17 WO disclosed
WO-1996004261-A1 BENZOXAZOLES AND PRYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF THE TYPE II DIABETES SMITHKLINE BEECHAM PLC (GB) 1996-02-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260130872-A1 Substituted Bicyclic Compounds, Compositions and Methods of Use GIPR, GLP1R, SIGMAR1 PPARG 790/4885PPARA 2483/4885
US-12595248-B2 PRMT5 inhibitors PRMT5, PRMT1, PRMT6 PPARG 4438/4885PPARA 4662/4885
US-12595262-B2 PRMT5 inhibitors PRMT1, PRMT5, CARM1 PPARG 3888/4885PPARA 3780/4885
US-20020082258-A1 Novel bicyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them SLC5A1, CYP11B1, CYP4A11 PPARG 618/4885PPARA 884/4885
US-20260132119-A1 Alkylphenyl Substituted Compounds, Compositions and Methods of Use GIPR, MC2R, GRPR PPARG 473/4885PPARA 1636/4885
US-20260132164-A1 PNU ANTHRACYCLINE DERIVATIVES AND METHODS OF USE THEREOF TOP1, NCL, NOLC1 PPARG 3339/4885PPARA 2387/4885
US-12611401-B2 Combinations comprising benzodioxol as GLP-1R agonists for use in the treatment of NASH/NAFLD and related diseases GLP1R, GCKR, GPR119 PPARG 12/4885PPARA 39/4885
US-20020103215-A1 New monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them CYP11B1, CYP46A1, CYP27A1 PPARG 133/4885PPARA 176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.